‘Mother(Nature) knows best’ – hijacking nature-designed transcriptional programs for enhancing stress resistance and protein production in Yarrowia lipolytica; presentation of YaliFunTome database

• Published in: Microbial cell factories Vol. 23; no. 1; pp. 1 - 20
• Main Authors: Gorczyca, Maria, Białas, Wojciech, Nicaud, Jean-Marc, Celińska, Ewelina
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 18.01.2024; BioMed Central; BMC
• Subjects: Analysis; Carbon; Design of experiments; DNA binding proteins; Engineering; Experimental design; Genomes; Genotype & phenotype; Global metabolic engineering; Glycerol; Health aspects; Identification and classification; Life Sciences; Mathematical models; Medicinal plants; Metabolism; Metabolites; Nitrogen; Oxidative stress; Phenotypes; Protein biosynthesis; Protein production; Protein synthesis; Proteins; Reporters; RNA polymerase; Strains (organisms); Stress resistance; Transcription factors; Yarrow; Yarrowia cultivation protocol; Yarrowia lipolytica; Yeast; France; Poland; Transcription factors; Yeast; Protein production; Stress resistance; Global metabolic engineering; Yarrowia cultivation protocol

In the era of rationally designed synthetic biology, heterologous metabolites production, and other counter-nature engineering of cellular metabolism, we took a step back and recalled that 'Mother(-Nature) knows best'. While still aiming at synthetic, non-natural outcomes of generating an...