Gene expression changes induced by ochratoxin A in renal and hepatic tissues of male F344 rat after oral repeated administration

• Published in: Toxicology and applied pharmacology Vol. 230; no. 2; pp. 197 - 207
• Main Authors: Arbillaga, Leire, Vettorazzi, Ariane, Gil, Ana G, van Delft, Joost HM, García-Jalón, José Antonio, López de Cerain, Adela
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 15.07.2008; Elsevier
• Subjects: 60 APPLIED LIFE SCIENCES; Administration, Oral; Animals; Annexins - metabolism; Biological and medical sciences; BIOLOGICAL PATHWAYS; Body Weight - drug effects; CALCIUM; Calcium - metabolism; CARCINOGENS; DNA DAMAGES; Gene expression; Gene Expression - drug effects; GENES; HOMEOSTASIS; Homeostasis - drug effects; IN VITRO; IN VIVO; Kidney - drug effects; Kidney - metabolism; kidney and liver OTA accumulation; KIDNEYS; LIVER; Liver - drug effects; Liver - metabolism; Male; Male Fisher 344 rat; Medical sciences; METABOLISM; MICROTUBULES; NECROSIS; Ochratoxin A; Ochratoxins - pharmacokinetics; Ochratoxins - pharmacology; Ochratoxins - toxicity; Oligonucleotide Array Sequence Analysis; OXIDATION; Oxidative Stress - drug effects; Plant poisons toxicology; RATS; Rats, Inbred F344; Repeated oral toxicity; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - analysis; RNA, Messenger - biosynthesis; TIME DEPENDENCE; TOXICITY; Toxicology; kidney and liver OTA accumulation; Male Fisher 344 rat; Gene expression; Ochratoxin A; Repeated oral toxicity; Ochratoxin; Rat; Digestive system; Liver; Mycotoxin; Rodentia; Oral administration; Male; Kidney; Multiple dose; Toxin; Tissue; Vertebrata; Mammalia; Urinary system; Animal; Biological accumulation; Ochratoxin A;Gene expression;Repeated oral toxicity;Male Fisher 344 rat;kidney and liver OTA accumulation

Ochratoxin A (OTA), a naturally occurring mycotoxin, is nephrotoxic in all animal species tested and is considered a potent renal carcinogen, particularly in male rats. Its mechanism of toxicity is still unknown, although oxidative stress appears to be a plausible mechanism. Therefore, the objective...