A Multidimensional Characterization of E3 Ubiquitin Ligase and Substrate Interaction Network

• Published in: iScience Vol. 16; pp. 177 - 191
• Main Authors: Chen, Di, Liu, Xiaolong, Xia, Tian, Tekcham, Dinesh Singh, Wang, Wen, Chen, Huan, Li, Tongming, Lu, Chang, Ning, Zhen, Liu, Xiumei, Liu, Jing, Qi, Huan, He, Hui, Piao, Hai-long
• Format: Journal Article
• Language: English
• Published: United States Elsevier 28.06.2019
• Subjects: Molecular Network; Bioinformatics; Systems Biology; Proteomics

E3 ubiquitin ligases (E3s) play a critical role in molecular and cellular mechanisms. However, a large number of E3-substrate interactions (ESIs) remain unrevealed. Here, we integrated the increasing omics data with biological knowledge to characterize and identify ESIs. Multidimensional features we...