Nitric oxide regulation of asthmatic airway inflammation with segmental allergen challenge

• Published in: Journal of allergy and clinical immunology Vol. 104; no. 6; pp. 1174 - 1182
• Main Authors: Thomassen, Mary Jane, Raychaudhuri, Baisakhi, Dweik, Raed A., Farver, Carol, Buhrow, Lisa, Malur, Anagha, Connors, Mary J., Drazba, Judy, Hammel, Jeffrey, Erzurum, Serpil C., Kavuru, Mani S.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York, NY Mosby, Inc 01.12.1999; Elsevier
• Subjects: activator protein-1; Adult; Allergens - pharmacology; Allergic diseases; Alveolar macrophage; asthma; Asthma - physiopathology; Biological and medical sciences; Bronchoalveolar Lavage Fluid - cytology; Chemokine CCL4; Cytokines - metabolism; Eosinophils - cytology; Female; Granulocyte-Macrophage Colony-Stimulating Factor - metabolism; Humans; Immunopathology; Inflammation - metabolism; Leukocyte Count - drug effects; macrophage inflammatory protein 1; Macrophage Inflammatory Proteins - metabolism; Male; Medical sciences; Middle Aged; NF-^KB protein; NF-kappa B - pharmacology; nitric oxide; Nitric Oxide - pharmacology; nuclear factor-κB; Respiratory and ent allergic diseases; segmental allergen challenge; Transcription Factor AP-1 - pharmacology; transcription factors; Transcription Factors - pharmacology; NO; nitric oxide; transcription factors; activator protein-1; asthma; PD 20; AP-1; BAL; nuclear factor-κB; NF-κB; SAC; Alveolar macrophage; EMSA; PNU; MIP-1α; WCE; segmental allergen challenge; ELF; Human; Immunopathology; Allergy; Pathophysiology; Respiratory disease; Cytokine; Inflammation; Biological activity; Asthma; Respiratory tract; Regulation(control); Nitric oxide; Obstructive pulmonary disease; Transcription factor NFκB; Transcription factor
• ISSN: 0091-6749
• DOI: 10.1016/S0091-6749(99)70010-2

Background: Despite evidence of increased nitric oxide (NO) in asthmatic compared with healthy individuals, the role of NO in airway inflammation is unclear. Objective: The purpose of the study was to determine the in vivo effects of localized allergen challenge on airway NO levels and transcription...