FMRP Interacts with C/D Box snoRNA in the Nucleus and Regulates Ribosomal RNA Methylation

• Published in: iScience Vol. 9; pp. 399 - 411
• Main Authors: D'Souza, Michelle Ninochka, Gowda, Naveen Kumar Chandappa, Tiwari, Vishal, Babu, Rosana Ottakandathil, Anand, Praveen, Dastidar, Sudhriti Ghosh, Singh, Randhir, James, Owen G., Selvaraj, Bhuvaneish, Pal, Rakhi, Ramesh, Arati, Chattarji, Sumantra, Chandran, Siddharthan, Gulyani, Akash, Palakodeti, Dasaradhi, Muddashetty, Ravi S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier 30.11.2018
• Subjects: Molecular Interaction; Stem Cells Research; Omics

FMRP is an RNA-binding protein that is known to localize in the cytoplasm and in the nucleus. Here, we have identified an interaction of FMRP with a specific set of C/D box snoRNAs in the nucleus. C/D box snoRNAs guide 2'O methylations of ribosomal RNA (rRNA) on defined sites, and this modifica...