Gut Microbiota Characterization in Patients with Asymptomatic Hyperuricemia: probiotics increased

• Published in: Bioengineered Vol. 12; no. 1; pp. 7263 - 7275
• Main Authors: Yang, Hai-Tao, Xiu, Wen-Juan, Liu, Jing-Kun, Yang, Yi, Hou, Xian-Geng, Zheng, Ying-Ying, Wu, Ting-Ting, Wu, Chen-Xin, Xie, Xiang
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.01.2021
• Subjects: 16s rRNA gene; Aged; Asymptomatic Diseases; Asymptomatic hyperuricemia; Bacteria - genetics; diagnostic model; Feces - microbiology; Female; Gastrointestinal Microbiome - genetics; gut microbiota; Humans; Hyperuricemia - epidemiology; Hyperuricemia - microbiology; Male; Middle Aged; Probiotics; Research Paper; Asymptomatic hyperuricemia; diagnostic model; 16s rRNA gene; gut microbiota; probiotics
• ISSN: 2165-5979; 2165-5987; 2165-5987
• DOI: 10.1080/21655979.2021.1976897

Asymptomatic hyperuricemia (AH) is an early stage of gout. Emerging evidence shows that the intestinal microbiota is related to gout. However, the relationship between AH and the intestinal microbiota is poorly understood. Therefore, the aim of the current study was to explore the possible correlation between AH and intestinal flora. We compared the intestinal microbial communities of AH (45 cases) and healthy subjects (45 cases) by 16S rRNA gene sequencing and clustering analysis on the incorporated population. Intestinal-type clustering can be divided into two groups, and significant differences in the proportion of AH are found among different bowel types. Alpha diversity indices were higher in the AH group than in the control group, and beta diversity indices also showed significant differences. A total of 19 genera were found different between the AH group and the control group. Compared with the control group, some probiotics are increased in the AH population. Two groups were ranked by importance of bacteria. We found the different bacteria partially coincided with the important bacteria, and the joint diagnosis level of the important bacteria was good. Conclusion: There were significant differences in the composition of intestinal biota between AH patients and healthy subjects. Some probiotics increased in AH.