Interchromosomal translocation in neural progenitor cells exposed to L1 retrotransposition

• Published in: Genetics and molecular biology Vol. 46; no. 1; p. e20220268
• Main Author: Muotri, Alysson R
• Format: Journal Article
• Language: English; Portuguese
• Published: Brazil Sociedade Brasileira de Genética 01.01.2023
• Subjects: BIOCHEMISTRY & MOLECULAR BIOLOGY; brain mosaicism; Cellular, Molecular and Developmental Genetics; GENETICS & HEREDITY; L1 retrotransposition; neural progenitor cells; translocations; translocations; brain mosaicism; L1 retrotransposition; neural progenitor cells

LINE-1 (L1) elements are a class of transposons, comprising approximately 19% and 21% of the mouse and human genomes, respectively. L1 retrotransposons can reverse transcribe their own RNA sequence into a de novo DNA copy integrated into a new genomic location. This activity, known as retrotransposi...