Microtubule stabilization promotes the synthesis of type 2 collagen in nucleus pulposus cell by activating hippo-yap pathway

• Published in: Frontiers in pharmacology Vol. 14; p. 1102318
• Main Authors: Zhang, Xin, Shu, Shibin, Feng, Zhenhua, Qiu, Yong, Bao, Hongda, Zhu, Zezhang
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 26.01.2023
• Subjects: intervertebral disc; intervertebral disc degeneration; mechanical stress; microtubule stabilization; nucleus pulposus; Pharmacology; intervertebral disc degeneration; mechanical stress; intervertebral disc; nucleus pulposus; microtubule stabilization

Intervertebral disc degeneration (IDD) is the cardinal pathological mechanism that underlies low back pain. Mechanical stress of the intervertebral disc may result in a change in nucleus pulposus cells state, matrix degradation, and degeneration of the disc. Microtubules, which are components of the...