Causal associations of obesity related anthropometric indicators and body compositions with knee and hip arthritis: A large-scale genetic correlation study

• Published in: Frontiers in endocrinology (Lausanne) Vol. 13; p. 1011896
• Main Authors: Wang, Chao, Zhu, Yong, Liu, Zhi, Long, Haitao, Ruan, Zhe, Zhao, Shushan
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 29.09.2022
• Subjects: anthropometric measurement; Body Composition - genetics; body compositions; Body Mass Index; Correlation of Data; Endocrinology; genetic correlation; Genome-Wide Association Study; hip arthritis; Humans; knee arthritis; obesity; Obesity - complications; Obesity - epidemiology; Obesity - genetics; Osteoarthritis, Hip - etiology; Osteoarthritis, Hip - genetics; Osteoarthritis, Knee - etiology; Osteoarthritis, Knee - genetics; knee arthritis; anthropometric measurement; body compositions; causal association; Mendelian randomization; genetic correlation; hip arthritis; obesity

Epidemiological studies have repeatedly investigated the association between obesity related anthropometric indicators and body compositions and osteoarthritis (OA). However, the results have remained inconsistent. This work aimed to investigate the genetic correlation and causal associations of obe...