Analysis on heterogeneity of hepatocellular carcinoma immune cells and a molecular risk model by integration of scRNA-seq and bulk RNA-seq

• Published in: Frontiers in immunology Vol. 13; p. 1012303
• Main Authors: Liu, Xiaorui, Li, Jingjing, Wang, Qingxiang, Bai, Lu, Xing, Jiyuan, Hu, Xiaobo, Li, Shuang, Li, Qinggang
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 13.10.2022
• Subjects: autophagy; Carcinoma, Hepatocellular - pathology; hcc; Humans; Immunology; Liver Neoplasms - pathology; molecular subtypes; Nomograms; riskscore; RNA-Seq; ScRNA-seq; Single-Cell Analysis; ScRNA-seq; riskscore; molecular subtypes; hcc; autophagy

Studies have shown that hepatocellular carcinoma (HCC) heterogeneity is a main cause leading to failure of treatment. Technology of single-cell sequencing (scRNA) could more accurately reveal the essential characteristics of tumor genetics. From the Gene Expression Omnibus (GEO) database, HCC scRNA-...