Augmenting ATG14 alleviates atherosclerosis and inhibits inflammation via promotion of autophagosome-lysosome fusion in macrophages

• Published in: Autophagy Vol. 17; no. 12; pp. 4218 - 4230
• Main Authors: Zhang, Hui, Ge, Song, Ni, Buqing, He, Keshuai, Zhu, Pengcheng, Wu, Xiaohong, Shao, Yongfeng
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 02.12.2021
• Subjects: Animals; ATG14; atherosclerosis; Atherosclerosis - pathology; Autophagosomes - metabolism; Autophagy; inflammation; Inflammation - metabolism; Leukocytes, Mononuclear - metabolism; lipid degradation; Lysosomes - metabolism; Macroautophagy; Macrophages - metabolism; Mice; Research Paper; atherosclerosis; autophagy; ATG14; inflammation; lipid degradation

Dysfunction of macroautophagy/autophagy in macrophages contributes to atherosclerosis. Impaired autophagy-lysosomal degradation system leads to lipid accumulation, facilitating atherosclerotic plaque. ATG14 is an essential regulator for the fusion of autophagosomes with lysosomes. Whether ATG14 play...