Emerging predictive biomarkers for novel therapeutics in peripheral T-cell and natural killer/T-cell lymphoma

• Published in: Frontiers in immunology Vol. 14; p. 1068662
• Main Authors: Yap, Daniel Ren Yi, Lim, Jing Quan, Huang, Dachuan, Ong, Choon Kiat, Chan, Jason Yongsheng
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 26.01.2023
• Subjects: Biomarkers; checkpoint immunotherapy; genomics; Humans; Immunology; Immunotherapy; Killer Cells, Natural - pathology; Lymphoma, T-Cell, Peripheral - drug therapy; precision oncology; targeted therapy; Treatment Outcome; tumor microenvironment; checkpoint immunotherapy; precision oncology; targeted therapy; genomics; tumor microenvironment

Peripheral T-cell lymphoma (PTCL) and natural killer/T-cell lymphoma (NKTCL) are rare subtypes of non-Hodgkin’s lymphoma that are typically associated with poor treatment outcomes. Contemporary first-line treatment strategies generally involve the use of combination chemoimmunotherapy, radiation and...