Elicitation of Andrographolide in the Suspension Cultures of Andrographis paniculata

Andrographis paniculata belonging to the family Acanthaceae produces a group of diterpene lactones, one of which is the pharmaceutically important—andrographolide. It is known to possess various important biological properties like anticancer, anti-HIV, anti-inflammatory, etc. This is the first repo...

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Published inApplied biochemistry and biotechnology Vol. 168; no. 7; pp. 1729 - 1738
Main Authors Gandi, Suryakala, Rao, Kiranmayee, Chodisetti, Bhuvaneswari, Giri, Archana
Format Journal Article
LanguageEnglish
Published New York Springer-Verlag 01.12.2012
Springer
Springer Nature B.V
Subjects
Abiotic stress
Acanthaceae
Agrobacterium radiobacter
Agrobacterium rhizogenes
Agrobacterium tumefaciens
Andrographis
Andrographis - drug effects
Andrographis - growth & development
Andrographis - metabolism
Andrographis - microbiology
Andrographis paniculata
Bacillus subtilis
Bacterial Physiological Phenomena
Biochemistry
Biological and medical sciences
Biological properties
Biotechnology
cell suspension culture
Chemistry
Chemistry and Materials Science
Culture Techniques
Culture Techniques - methods
Diterpenes
Diterpenes - metabolism
drug effects
E coli
Escherichia coli
Fundamental and applied biological sciences. Psychology
growth & development
Human immunodeficiency virus
lactones
metabolism
Metals
Metals - pharmacology
methods
microbiology
pathogens
pharmacology
Rhizobium rhizogenes
Suspensions
Yeast
Yeasts
Suspension cultures
Elicitation
Andrographolide
Abiotic
Biotic
Suspension culture
Environmental factor
Andrographis paniculata
Abiotic factor
Online AccessGet full text
ISSN0273-2289
1559-0291
1559-0291
DOI10.1007/s12010-012-9892-4

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Abstract Andrographis paniculata belonging to the family Acanthaceae produces a group of diterpene lactones, one of which is the pharmaceutically important—andrographolide. It is known to possess various important biological properties like anticancer, anti-HIV, anti-inflammatory, etc. This is the first report on the production of andrographolide in the cell suspension cultures of Andrographis paniculata by ‘elicitation’. Elicitation was attempted to enhance the andrographolide content in the suspension cultures of Andrographis paniculata and also to ascertain its stimulation under stress conditions or in response to pathogen attack. The maximum andrographolide production was found to be 1.53 mg/g dry cell weight (DCW) at the end of stationary phase during the growth curve. The biotic elicitors (yeast, Escherichia coli , Bacillus subtilis , Agrobacterium rhizogenes 532 and Agrobacterium tumefaciens C 58) were more effective in eliciting the response when compared to the abiotic elicitors (CdCl 2 , AgNO 3 , CuCl 2 and HgCl 2 ). Yeast has shown to stimulate maximum accumulation of 13.5 mg/g DCW andrographolide, which was found to be 8.82-fold higher than the untreated cultures.
AbstractList Andrographis paniculata belonging to the family Acanthaceae produces a group of diterpene lactones, one of which is the pharmaceutically important—andrographolide. It is known to possess various important biological properties like anticancer, anti-HIV, anti-inflammatory, etc. This is the first report on the production of andrographolide in the cell suspension cultures of Andrographis paniculata by ‘elicitation’. Elicitation was attempted to enhance the andrographolide content in the suspension cultures of Andrographis paniculata and also to ascertain its stimulation under stress conditions or in response to pathogen attack. The maximum andrographolide production was found to be 1.53 mg/g dry cell weight (DCW) at the end of stationary phase during the growth curve. The biotic elicitors (yeast, Escherichia coli, Bacillus subtilis, Agrobacterium rhizogenes 532 and Agrobacterium tumefaciens C 58) were more effective in eliciting the response when compared to the abiotic elicitors (CdCl₂, AgNO₃, CuCl₂ and HgCl₂). Yeast has shown to stimulate maximum accumulation of 13.5 mg/g DCW andrographolide, which was found to be 8.82-fold higher than the untreated cultures.
Andrographis paniculata belonging to the family Acanthaceae produces a group of diterpene lactones, one of which is the pharmaceutically important -- andrographolide. It is known to possess various important biological properties like anticancer, anti-HIV, anti-inflammatory, etc. This is the first report on the production of andrographolide in the cell suspension cultures of Andrographis paniculata by elicitation. Elicitation was attempted to enhance the andrographolide content in the suspension cultures of Andrographis paniculata and also to ascertain its stimulation under stress conditions or in response to pathogen attack. The maximum andrographolide production was found to be 1.53 mg/g dry cell weight (DCW) at the end of stationary phase during the growth curve. The biotic elicitors (yeast, Escherichia coli, Bacillus subtilis, Agrobacterium rhizogenes 532 and Agrobacterium tumefaciens C 58) were more effective in eliciting the response when compared to the abiotic elicitors (CdCl^sub 2^, AgNO3, CuCl^sub 2^ and HgCl^sub 2^). Yeast has shown to stimulate maximum accumulation of 13.5 mg/g DCW andrographolide, which was found to be 8.82-fold higher than the untreated cultures.[PUBLICATION ABSTRACT]
Andrographis paniculata belonging to the family Acanthaceae produces a group of diterpene lactones, one of which is the pharmaceutically important-andrographolide. It is known to possess various important biological properties like anticancer, anti-HIV, anti-inflammatory, etc. This is the first report on the production of andrographolide in the cell suspension cultures of Andrographis paniculata by 'elicitation'. Elicitation was attempted to enhance the andrographolide content in the suspension cultures of Andrographis paniculata and also to ascertain its stimulation under stress conditions or in response to pathogen attack. The maximum andrographolide production was found to be 1.53 mg/g dry cell weight (DCW) at the end of stationary phase during the growth curve. The biotic elicitors (yeast, Escherichia coli, Bacillus subtilis, Agrobacterium rhizogenes 532 and Agrobacterium tumefaciens C 58) were more effective in eliciting the response when compared to the abiotic elicitors (CdCl sub(2), AgNO sub(3), CuCl sub(2) and HgCl sub(2)). Yeast has shown to stimulate maximum accumulation of 13.5 mg/g DCW andrographolide, which was found to be 8.82-fold higher than the untreated cultures.
Andrographis paniculata belonging to the family Acanthaceae produces a group of diterpene lactones, one of which is the pharmaceutically important-andrographolide. It is known to possess various important biological properties like anticancer, anti-HIV, anti-inflammatory, etc. This is the first report on the production of andrographolide in the cell suspension cultures of Andrographis paniculata by 'elicitation'. Elicitation was attempted to enhance the andrographolide content in the suspension cultures of Andrographis paniculata and also to ascertain its stimulation under stress conditions or in response to pathogen attack. The maximum andrographolide production was found to be 1.53 mg/g dry cell weight (DCW) at the end of stationary phase during the growth curve. The biotic elicitors (yeast, Escherichia coli, Bacillus subtilis, Agrobacterium rhizogenes 532 and Agrobacterium tumefaciens C 58) were more effective in eliciting the response when compared to the abiotic elicitors (CdCl(2), AgNO(3), CuCl(2) and HgCl(2)). Yeast has shown to stimulate maximum accumulation of 13.5 mg/g DCW andrographolide, which was found to be 8.82-fold higher than the untreated cultures.
Andrographis paniculata belonging to the family Acanthaceae produces a group of diterpene lactones, one of which is the pharmaceutically important—andrographolide. It is known to possess various important biological properties like anticancer, anti-HIV, anti-inflammatory, etc. This is the first report on the production of andrographolide in the cell suspension cultures of Andrographis paniculata by ‘elicitation’. Elicitation was attempted to enhance the andrographolide content in the suspension cultures of Andrographis paniculata and also to ascertain its stimulation under stress conditions or in response to pathogen attack. The maximum andrographolide production was found to be 1.53 mg/g dry cell weight (DCW) at the end of stationary phase during the growth curve. The biotic elicitors (yeast, Escherichia coli , Bacillus subtilis , Agrobacterium rhizogenes 532 and Agrobacterium tumefaciens C 58) were more effective in eliciting the response when compared to the abiotic elicitors (CdCl 2 , AgNO 3 , CuCl 2 and HgCl 2 ). Yeast has shown to stimulate maximum accumulation of 13.5 mg/g DCW andrographolide, which was found to be 8.82-fold higher than the untreated cultures.
Andrographis paniculata belonging to the family Acanthaceae produces a group of diterpene lactones, one of which is the pharmaceutically important-andrographolide. It is known to possess various important biological properties like anticancer, anti-HIV, anti-inflammatory, etc. This is the first report on the production of andrographolide in the cell suspension cultures of Andrographis paniculata by 'elicitation'. Elicitation was attempted to enhance the andrographolide content in the suspension cultures of Andrographis paniculata and also to ascertain its stimulation under stress conditions or in response to pathogen attack. The maximum andrographolide production was found to be 1.53 mg/g dry cell weight (DCW) at the end of stationary phase during the growth curve. The biotic elicitors (yeast, Escherichia coli, Bacillus subtilis, Agrobacterium rhizogenes 532 and Agrobacterium tumefaciens C 58) were more effective in eliciting the response when compared to the abiotic elicitors (CdCl(2), AgNO(3), CuCl(2) and HgCl(2)). Yeast has shown to stimulate maximum accumulation of 13.5 mg/g DCW andrographolide, which was found to be 8.82-fold higher than the untreated cultures.Andrographis paniculata belonging to the family Acanthaceae produces a group of diterpene lactones, one of which is the pharmaceutically important-andrographolide. It is known to possess various important biological properties like anticancer, anti-HIV, anti-inflammatory, etc. This is the first report on the production of andrographolide in the cell suspension cultures of Andrographis paniculata by 'elicitation'. Elicitation was attempted to enhance the andrographolide content in the suspension cultures of Andrographis paniculata and also to ascertain its stimulation under stress conditions or in response to pathogen attack. The maximum andrographolide production was found to be 1.53 mg/g dry cell weight (DCW) at the end of stationary phase during the growth curve. The biotic elicitors (yeast, Escherichia coli, Bacillus subtilis, Agrobacterium rhizogenes 532 and Agrobacterium tumefaciens C 58) were more effective in eliciting the response when compared to the abiotic elicitors (CdCl(2), AgNO(3), CuCl(2) and HgCl(2)). Yeast has shown to stimulate maximum accumulation of 13.5 mg/g DCW andrographolide, which was found to be 8.82-fold higher than the untreated cultures.
Author Gandi, Suryakala
Rao, Kiranmayee
Giri, Archana
Chodisetti, Bhuvaneswari
Author_xml – sequence: 1
  givenname: Suryakala
  surname: Gandi
  fullname: Gandi, Suryakala
  organization: Centre for Biotechnology, Institute of Science and Technology, Jawaharlal Nehru Technological University Hyderabad
– sequence: 2
  givenname: Kiranmayee
  surname: Rao
  fullname: Rao, Kiranmayee
  organization: Centre for Biotechnology, Institute of Science and Technology, Jawaharlal Nehru Technological University Hyderabad
– sequence: 3
  givenname: Bhuvaneswari
  surname: Chodisetti
  fullname: Chodisetti, Bhuvaneswari
  organization: Centre for Biotechnology, Institute of Science and Technology, Jawaharlal Nehru Technological University Hyderabad
– sequence: 4
  givenname: Archana
  surname: Giri
  fullname: Giri, Archana
  email: archanagiriin@yahoo.co.in
  organization: Centre for Biotechnology, Institute of Science and Technology, Jawaharlal Nehru Technological University Hyderabad
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IsPeerReviewed true
IsScholarly true
Issue 7
Keywords Suspension cultures
Elicitation
Andrographolide
Abiotic
Biotic
Suspension culture
Environmental factor
Andrographis paniculata
Abiotic factor
Language English
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PublicationSubtitle Part A: Enzyme Engineering and Biotechnology
PublicationTitle Applied biochemistry and biotechnology
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KrolickaAKartanowiczRWosinskiaSZpitterAKaminskiMLojkowskaEEnzyme and Microbial Technology2006391386138910.1016/j.enzmictec.2006.03.0421:CAS:528:DC%2BD28XpvFGht7g%3D
SheejaKShihabPKKuttanGImmunopharmacology and Immunotoxicology20062812914010.1080/089239706006260071:STN:280:DC%2BD283ms12nsg%3D%3D
LeonardERunguphanWConnorPratherKJNature Chemical Biology2009529230010.1038/nchembio.1601:CAS:528:DC%2BD1MXks12ktro%3D
OtakeTMoriHMorimotoMUebaNSutardjoSKusumotoITHattoriMNambaTPhytotherapy Research1995961010.1002/ptr.2650090103
KimHJChenFWangXRajapakseNCJournal of Agricultural and Food Chemistry20055393696370110.1021/jf04808041:CAS:528:DC%2BD2MXivV2msLY%3D
ZhaoJDavisLCVerpoorteRBiotechnology Advances20052328333310.1016/j.biotechadv.2005.01.0031:CAS:528:DC%2BD2MXjsVehu7c%3D
Visen, P. K. S., Saraswat, B., Vuksen, V., Dhawan, B. N.(2007). Journal of Complement and Integrated Medicine, 4–10.
LiJCheungHYZhangZChanGKLFongWFEuropean Journal of Pharmacology20073314410.1016/j.ejphar.2007.04.027
ZhangCHWuJYHeGYApplied Microbiology and Biotechnology20026039640210.1007/s00253-002-1130-51:CAS:528:DC%2BD38Xpt1Cjur0%3D
ChanderRSrivastavaVTandonJSKapoorNKPharmaceutical Biology19953313513810.3109/138802095090552131:CAS:528:DyaK2MXmslyjs7w%3D
BhuvaneswariC.KiranmayeeR.SuryakalaG.ArchanaG.World Journal of Microbiology and Biotechnology201228741747
BeenaMRMartinKPIn Vitro Cellular & Developmental Biology – Plant200339551051310.1079/IVP2003468
TrivediNRawalUMIndian Journal of Pharmacology200032288293
NasserWDe TapiaMKauffmannSKouhsariMSBurkardPlant Molecular Biology19881152953810.1007/BF00039033
CheungHYCheungSHLiLCheungCSLaiWPFongWFLeungFMPlanta Medica2005711106111110.1055/s-2005-8731281:CAS:528:DC%2BD28XotFCqsA%3D%3D
WykVBWinkMMedicinal plants of the world: an illustrated scientific guide to important medicinal plants and their uses2004PortlandTimber480
KumarRASrideviKKumarNVNanduriSRajagopalSJournal of Ethnopharmacology20049229129510.1016/j.jep.2004.03.0041:CAS:528:DC%2BD2cXjvVGmsb4%3D
ZhouJZhangSOngCShenHBiochemical Pharmacology20067213214410.1016/j.bcp.2006.04.0191:CAS:528:DC%2BD28Xls1altb8%3D
DassSRamawatKGPlant Cell Tissue Organ culture20099634935310.1007/s11240-008-9493-7
RaoSRRavishankarKABiotechnology Advances20022010115310.1016/S0734-9750(02)00007-11:STN:280:DC%2BD3svnsVejsg%3D%3D
SharmaAKrishanLHandaSSPhytochemical Analysis1952312913110.1002/pca.2800030308
TanBKHZhangCYPackerLOngCNHalliwellBAndrographis paniculata and the cardiovascular systemHerbal and traditional medicine: Molecular aspects on health2004TaipeiCRC441456
Abu-JawdahYPhytopathology198210327227910.1111/j.1439-0434.1982.tb01750.x1:CAS:528:DyaL38XktVeks7g%3D
KomaraiahPNagaARKavi KishorPBRamakrishnaSVEnzyme and Microbial Technology200231563463910.1016/S0141-0229(02)00159-X1:CAS:528:DC%2BD38XmvVCksb0%3D
De TapiaMBerbmanPAwadeABurkardGPlant Sciences19864516717710.1016/0168-9452(86)90136-6
JungHYKangSMKangYMKangMJYunDJBahkJDYangJKChoiMSEnzyme and Microbial Technology200333798799010.1016/S0141-0229(03)00253-91:CAS:528:DC%2BD3sXovVemsLY%3D
SharmaASinghRTSehgalVHandaSSFitoterapia199162131138
Sukardiman, H., Widyawaruyanti, A., Sismindari, Zaini, N. C. (2007). African Journal of Traditional Complement and Alternative Medicines, 4, 345–351
MasoumehKTaherehHSayyedKKTPlant Omics Journal201034109114
KoehnFECarterGTNature Reviews. Drug Discovery2005420622010.1038/nrd16571:CAS:528:DC%2BD2MXhslSnsrg%3D
LuczkiewiczMRamawatKGMerillonJMResearch into isoflavonoids: phytoestrogens in plant cell culturesBioactive molecules and medicinal plants2008BerlinSpringer5484
RajagopalSKumarRADeeviDSSatyanarayanaCRajagopalRJournal of Experimental Therapeutics and Onclogy2003314715810.1046/j.1359-4117.2003.01090.x1:CAS:528:DC%2BD3sXosF2mt74%3D
VijaiSKRinkiJPritiTDixitVKIn Vitro Cell and Developmental Biology—Plant20104635436210.1007/s11627-010-9278-7
ShenYCChenCFChiouWBritish Journal of Pharmacology200213539940610.1038/sj.bjp.07044931:CAS:528:DC%2BD38Xht1Krsbo%3D
AshishBSinghDVinodDKApplied Biochemistry and Biotechnology200815155656410.1007/s12010-008-8231-2
ShilpaKVarunKLakshmiBSJournal of Plant Science20105322224710.3923/jps.2010.222.247
FatimaBMuhammadASeemaIAsian journal of Scientific Research20082160165
LaryJHGarySMicrobiology reviews1986502193225
Tang, W., Eisenbrand, G., Chinese Drugs of Plant Origin. (1992). Chemistry, pharmacology, and use in traditional and modern medicine (pp. 97–103). Berlin: Springer
KimOTKimMYHongMHAhnJCHwangBPlant Cell Reports20042333934410.1007/s00299-004-0826-71:CAS:528:DC%2BD2cXptl2hu74%3D
DornenburgHKnorrDEnzyme and Microbial Technology19951767468410.1016/0141-0229(94)00108-4
BroecklingCDHuhmanDVFaragMASmithJTMayGDMendesPDixonRASumnerLWJournal of Experimental Botany20055641032333610.1093/jxb/eri0581:CAS:528:DC%2BD2MXkt1WltA%3D%3D
IruetagoyenaMITobarJAGonzalezPASepulvedaSEFigueroaCABurgosRAHanckeJLKalergisAMJournal of Pharmacology and Experimental Therapeutics20055366372
NamdeoAGPharmacognosy Reviews20071169791:CAS:528:DC%2BD2sXhtVSit7zL
MaridassMMaheshRRajuGMuthuchelianKInternational Journal of Bological Technology20101133371:CAS:528:DC%2BC3MXhsV2ltL3E
PraveenNManoharSHNaikPMNayeemAJeongJHMurthyHNCurrent Science20099656946971:CAS:528:DC%2BD1MXksl2qt7Y%3D
JiangLZZhouLGWuJYApplied Microbiology and Biotechnology20108713714410.1007/s00253-010-2443-4
LiuYHLiangZSChenBYangDFLiuJLEnzyme and Microbial Technology200946283110.1016/j.enzmictec.2009.08.0051:CAS:528:DC%2BC3cXisVyhsLg%3D
WiartCKumarKYusofMYHamimahHFauziZMSulaimanMPhytotherapy Research2005191069107010.1002/ptr.17651:CAS:528:DC%2BD28Xhs1agsLc%3D
EnriqueOMartoAnez-SolanoJRPiquerasAHelloEJournal of Experimental Botany20035429130110.1093/jxb/erg028
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HJ Kim (9892_CR29) 2005; 53
T Otake (9892_CR20) 1995; 9
W Nasser (9892_CR49) 1988; 1
9892_CR9
9892_CR18
9892_CR15
YH Liu (9892_CR54) 2009; 46
AG Namdeo (9892_CR33) 2007; 1
M Maridass (9892_CR39) 2010; 1
OT Kim (9892_CR32) 2004; 23
MI Iruetagoyena (9892_CR21) 2005; 5
MR Beena (9892_CR38) 2003; 39
CD Broeckling (9892_CR30) 2005; 56
S Handa (9892_CR6) 1990; 92
M Luczkiewicz (9892_CR24) 2008
C Calabrese (9892_CR19) 2000; 14
A Krolicka (9892_CR28) 2006; 39
N Praveen (9892_CR41) 2009; 96
S Rajagopal (9892_CR12) 2003; 3
J Zhao (9892_CR46) 2005; 23
C Wiart (9892_CR5) 2005; 19
KS Ham (9892_CR50) 1991; 4
B Ashish (9892_CR35) 2008; 151
VB Wyk (9892_CR31) 2004
A Sharma (9892_CR40) 1952; 3
HY Cheung (9892_CR13) 2005; 71
SR Rao (9892_CR23) 2002; 20
FE Koehn (9892_CR1) 2005; 4
References_xml – reference: KumarRASrideviKKumarNVNanduriSRajagopalSJournal of Ethnopharmacology20049229129510.1016/j.jep.2004.03.0041:CAS:528:DC%2BD2cXjvVGmsb4%3D
– reference: ZhouJZhangSOngCShenHBiochemical Pharmacology20067213214410.1016/j.bcp.2006.04.0191:CAS:528:DC%2BD28Xls1altb8%3D
– reference: ChanderRSrivastavaVTandonJSKapoorNKPharmaceutical Biology19953313513810.3109/138802095090552131:CAS:528:DyaK2MXmslyjs7w%3D
– reference: PraveenNManoharSHNaikPMNayeemAJeongJHMurthyHNCurrent Science20099656946971:CAS:528:DC%2BD1MXksl2qt7Y%3D
– reference: ZhangCHWuJYHeGYApplied Microbiology and Biotechnology20026039640210.1007/s00253-002-1130-51:CAS:528:DC%2BD38Xpt1Cjur0%3D
– reference: MasoumehKTaherehHSayyedKKTPlant Omics Journal201034109114
– reference: KoehnFECarterGTNature Reviews. Drug Discovery2005420622010.1038/nrd16571:CAS:528:DC%2BD2MXhslSnsrg%3D
– reference: OtakeTMoriHMorimotoMUebaNSutardjoSKusumotoITHattoriMNambaTPhytotherapy Research1995961010.1002/ptr.2650090103
– reference: ShenYCChenCFChiouWBritish Journal of Pharmacology200213539940610.1038/sj.bjp.07044931:CAS:528:DC%2BD38Xht1Krsbo%3D
– reference: BroecklingCDHuhmanDVFaragMASmithJTMayGDMendesPDixonRASumnerLWJournal of Experimental Botany20055641032333610.1093/jxb/eri0581:CAS:528:DC%2BD2MXkt1WltA%3D%3D
– reference: JiangLZZhouLGWuJYApplied Microbiology and Biotechnology20108713714410.1007/s00253-010-2443-4
– reference: KomaraiahPNagaARKavi KishorPBRamakrishnaSVEnzyme and Microbial Technology200231563463910.1016/S0141-0229(02)00159-X1:CAS:528:DC%2BD38XmvVCksb0%3D
– reference: RajagopalSKumarRADeeviDSSatyanarayanaCRajagopalRJournal of Experimental Therapeutics and Onclogy2003314715810.1046/j.1359-4117.2003.01090.x1:CAS:528:DC%2BD3sXosF2mt74%3D
– reference: KrolickaAKartanowiczRWosinskiaSZpitterAKaminskiMLojkowskaEEnzyme and Microbial Technology2006391386138910.1016/j.enzmictec.2006.03.0421:CAS:528:DC%2BD28XpvFGht7g%3D
– reference: Tang, W., Eisenbrand, G., Chinese Drugs of Plant Origin. (1992). Chemistry, pharmacology, and use in traditional and modern medicine (pp. 97–103). Berlin: Springer
– reference: HamKSKauffmannSAlbersheimPDarvillAGHost pathogen Interactions XXXIX. A soybean pathogenesis-related protein with b-1, 3-glucanase activity releases phytoalexin elicitor-active heat stable fragments from fungal wallsMolecular Plant-Microbe Interactions1991454555210.1094/MPMI-4-5451:CAS:528:DyaK38XhvVGgsQ%3D%3D
– reference: ShilpaKVarunKLakshmiBSJournal of Plant Science20105322224710.3923/jps.2010.222.247
– reference: LaryJHGarySMicrobiology reviews1986502193225
– reference: KimOTKimMYHongMHAhnJCHwangBPlant Cell Reports20042333934410.1007/s00299-004-0826-71:CAS:528:DC%2BD2cXptl2hu74%3D
– reference: TrivediNRawalUMIndian Journal of Pharmacology200032288293
– reference: WiartCKumarKYusofMYHamimahHFauziZMSulaimanMPhytotherapy Research2005191069107010.1002/ptr.17651:CAS:528:DC%2BD28Xhs1agsLc%3D
– reference: De TapiaMBerbmanPAwadeABurkardGPlant Sciences19864516717710.1016/0168-9452(86)90136-6
– reference: JungHYKangSMKangYMKangMJYunDJBahkJDYangJKChoiMSEnzyme and Microbial Technology200333798799010.1016/S0141-0229(03)00253-91:CAS:528:DC%2BD3sXovVemsLY%3D
– reference: IruetagoyenaMITobarJAGonzalezPASepulvedaSEFigueroaCABurgosRAHanckeJLKalergisAMJournal of Pharmacology and Experimental Therapeutics20055366372
– reference: DornenburgHKnorrDEnzyme and Microbial Technology19951767468410.1016/0141-0229(94)00108-4
– reference: CheungHYCheungSHLiLCheungCSLaiWPFongWFLeungFMPlanta Medica2005711106111110.1055/s-2005-8731281:CAS:528:DC%2BD28XotFCqsA%3D%3D
– reference: AjunglaLPatilPPBarmukhRBNikamTDIndian Journal of Biotechnology200983173221:CAS:528:DC%2BD1MXht1WisbzJ
– reference: Visen, P. K. S., Saraswat, B., Vuksen, V., Dhawan, B. N.(2007). Journal of Complement and Integrated Medicine, 4–10.
– reference: Sukardiman, H., Widyawaruyanti, A., Sismindari, Zaini, N. C. (2007). African Journal of Traditional Complement and Alternative Medicines, 4, 345–351
– reference: LeonardERunguphanWConnorPratherKJNature Chemical Biology2009529230010.1038/nchembio.1601:CAS:528:DC%2BD1MXks12ktro%3D
– reference: VijaiSKRinkiJPritiTDixitVKIn Vitro Cell and Developmental Biology—Plant20104635436210.1007/s11627-010-9278-7
– reference: FatimaBMuhammadASeemaIAsian journal of Scientific Research20082160165
– reference: DassSRamawatKGPlant Cell Tissue Organ culture20099634935310.1007/s11240-008-9493-7
– reference: Abu-JawdahYPhytopathology198210327227910.1111/j.1439-0434.1982.tb01750.x1:CAS:528:DyaL38XktVeks7g%3D
– reference: SharmaASinghRTSehgalVHandaSSFitoterapia199162131138
– reference: LiJCheungHYZhangZChanGKLFongWFEuropean Journal of Pharmacology20073314410.1016/j.ejphar.2007.04.027
– reference: WykVBWinkMMedicinal plants of the world: an illustrated scientific guide to important medicinal plants and their uses2004PortlandTimber480
– reference: BhuvaneswariC.KiranmayeeR.SuryakalaG.ArchanaG.World Journal of Microbiology and Biotechnology201228741747
– reference: SheejaKShihabPKKuttanGImmunopharmacology and Immunotoxicology20062812914010.1080/089239706006260071:STN:280:DC%2BD283ms12nsg%3D%3D
– reference: RaoSRRavishankarKABiotechnology Advances20022010115310.1016/S0734-9750(02)00007-11:STN:280:DC%2BD3svnsVejsg%3D%3D
– reference: TanBKHZhangCYPackerLOngCNHalliwellBAndrographis paniculata and the cardiovascular systemHerbal and traditional medicine: Molecular aspects on health2004TaipeiCRC441456
– reference: AshishBSinghDVinodDKApplied Biochemistry and Biotechnology200815155656410.1007/s12010-008-8231-2
– reference: MaridassMMaheshRRajuGMuthuchelianKInternational Journal of Bological Technology20101133371:CAS:528:DC%2BC3MXhsV2ltL3E
– reference: LiuYHLiangZSChenBYangDFLiuJLEnzyme and Microbial Technology200946283110.1016/j.enzmictec.2009.08.0051:CAS:528:DC%2BC3cXisVyhsLg%3D
– reference: KimHJChenFWangXRajapakseNCJournal of Agricultural and Food Chemistry20055393696370110.1021/jf04808041:CAS:528:DC%2BD2MXivV2msLY%3D
– reference: CalabreseCBermanSHBabishJGMaXShintoLDorrMWellsKWennerCAStandishLJPhytotherapy Research20001433333810.1002/1099-1573(200008)14:5<333::AID-PTR584>3.0.CO;2-D1:CAS:528:DC%2BD3cXmsVSqtbc%3D
– reference: NasserWDe TapiaMKauffmannSKouhsariMSBurkardPlant Molecular Biology19881152953810.1007/BF00039033
– reference: HandaSSharmaAIndian Journal of Medical Research1990922842921:STN:280:DyaK3M%2Fjtl2ktw%3D%3D
– reference: NamdeoAGPharmacognosy Reviews20071169791:CAS:528:DC%2BD2sXhtVSit7zL
– reference: ZhaoJDavisLCVerpoorteRBiotechnology Advances20052328333310.1016/j.biotechadv.2005.01.0031:CAS:528:DC%2BD2MXjsVehu7c%3D
– reference: SharmaAKrishanLHandaSSPhytochemical Analysis1952312913110.1002/pca.2800030308
– reference: BeenaMRMartinKPIn Vitro Cellular & Developmental Biology – Plant200339551051310.1079/IVP2003468
– reference: EnriqueOMartoAnez-SolanoJRPiquerasAHelloEJournal of Experimental Botany20035429130110.1093/jxb/erg028
– reference: LuczkiewiczMRamawatKGMerillonJMResearch into isoflavonoids: phytoestrogens in plant cell culturesBioactive molecules and medicinal plants2008BerlinSpringer5484
– volume: 14
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  year: 2000
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  publication-title: Phytotherapy Research
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  year: 2010
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Snippet Andrographis paniculata belonging to the family Acanthaceae produces a group of diterpene lactones, one of which is the pharmaceutically...
Andrographis paniculata belonging to the family Acanthaceae produces a group of diterpene lactones, one of which is the pharmaceutically...
Andrographis paniculata belonging to the family Acanthaceae produces a group of diterpene lactones, one of which is the pharmaceutically important --...
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StartPage 1729
SubjectTerms Abiotic stress
Acanthaceae
Agrobacterium radiobacter
Agrobacterium rhizogenes
Agrobacterium tumefaciens
Andrographis
Andrographis - drug effects
Andrographis - growth & development
Andrographis - metabolism
Andrographis - microbiology
Andrographis paniculata
Bacillus subtilis
Bacterial Physiological Phenomena
Biochemistry
Biological and medical sciences
Biological properties
Biotechnology
cell suspension culture
Chemistry
Chemistry and Materials Science
Culture Techniques
Culture Techniques - methods
Diterpenes
Diterpenes - metabolism
drug effects
E coli
Escherichia coli
Fundamental and applied biological sciences. Psychology
growth & development
Human immunodeficiency virus
lactones
metabolism
Metals
Metals - pharmacology
methods
microbiology
pathogens
pharmacology
Rhizobium rhizogenes
Suspensions
Yeast
Yeasts
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Title Elicitation of Andrographolide in the Suspension Cultures of Andrographis paniculata
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