Lisdexamfetamine reduces the compulsive and perseverative behaviour of binge-eating rats in a novel food reward/punished responding conflict model

• Published in: Journal of psychopharmacology (Oxford) Vol. 30; no. 7; pp. 662 - 675
• Main Authors: Heal, David J, Goddard, Simon, Brammer, Richard J, Hutson, Peter H, Vickers, Steven P
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.07.2016
• Subjects: Animals; Binge-Eating Disorder - drug therapy; Bulimia - drug therapy; Compulsive Behavior - drug therapy; Conditioning, Operant - drug effects; Feeding Behavior - drug effects; Female; Lisdexamfetamine Dimesylate - pharmacology; Rats; Rats, Wistar; Reward; compulsive; Lisdexamfetamine; perseverative; conflict model; binge eating

Compulsive and perseverative behaviour in binge-eating, female, Wistar rats was investigated in a novel food reward/punished responding conflict model. Rats were trained to perform the conditioned avoidance response task. When proficient, the paradigm was altered to a food-associated conflict test b...