Metabolic effects of CCL5 deficiency in lean and obese mice

• Published in: Frontiers in immunology Vol. 13; p. 1059687
• Main Authors: Zhou, Hui, Liao, Xiyan, Zeng, Qin, Zhang, Haowei, Song, Jianfeng, Hu, Wanyu, Sun, Xiaoxiao, Ding, Yujin, Wang, Dandan, Xiao, Yalun, Deng, Tuo
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 13.01.2023
• Subjects: adipose inflammation; Animals; CCL5; CD8-Positive T-Lymphocytes - metabolism; chemokine; Chemokine CCL5 - genetics; Chemokines; Immunology; Inflammation - metabolism; Insulin Resistance; Mice; Mice, Obese; obesity; Obesity - metabolism; chemokine; adipose inflammation; insulin resistance; CCL5; obesity

Accumulation and activation of immunocytes in adipose tissues are essential to obesity-induced inflammation and insulin resistance. Chemokines are pivotal for the recruitment of immunocytes in adipose tissue during obesity. Chemokine (C-C motif) ligand 5 (CCL5) plays a vital role in the recruitment...