Growth hormone stimulates lipolysis in mice but not in adipose tissue or adipocyte culture

• Published in: Frontiers in endocrinology (Lausanne) Vol. 13; p. 1028191
• Main Authors: Zhao, Lidan, Jiang, Honglin
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 04.01.2023
• Subjects: adipocytes; Adipocytes - metabolism; adipose tissue; Adipose Tissue - metabolism; adrenergic; Animals; Endocrinology; growth hormone; Growth Hormone - metabolism; Growth Hormone - pharmacology; Human Growth Hormone - metabolism; Human Growth Hormone - pharmacology; Isoproterenol - metabolism; Isoproterenol - pharmacology; Lipolysis; Mice; Receptors, Adrenergic, beta - metabolism; adipose tissue; adrenergic; growth hormone; lipolysis; adipocytes

The inhibitory effect of growth hormone (GH) on adipose tissue growth and the stimulatory effect of GH on lipolysis are well known, but the mechanisms underlying these effects are not completely understood. In this study, we revisited the effects of GH on adipose tissue growth and lipolysis in the l...