Wild-type SARS-CoV-2 neutralizing immunity decreases across variants and over time but correlates well with diagnostic testing

• Published in: Frontiers in immunology Vol. 14; p. 1055429
• Main Authors: O’Shea, Kelly M., Schuler, Charles F., Chen, Jesse, Troost, Jonathan P., Wong, Pamela T., Chen, Kelsea, O’Shea, Daniel R., Peng, Westley, Gherasim, Carmen, Manthei, David M., Valdez, Riccardo, Baldwin, James L., Baker, James R.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 08.02.2023
• Subjects: Antibodies, Neutralizing; antibody; Breakthrough Infections; COVID-19; COVID-19 - prevention & control; COVID-19 Testing; COVID-19 Vaccines; Diagnostic Techniques and Procedures; Humans; Immunoglobulin M; Immunology; SARS-CoV-2; spike; variant of concern; viral neutralization; COVID-19; nucleocapsid; SARS-CoV-2; vaccine; viral neutralization; antibody; variant of concern; spike

The degree of immune protection against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants provided by infection versus vaccination with wild-type virus remains unresolved, which could influence future vaccine strategies. The gold-standard for assessing immune protection is viral...