Improving lung function capacity in patients with chronotropic incompetence using closed loop stimulation: A randomized crossover study

• Published in: Journal of the Formosan Medical Association Vol. 124; no. 4; pp. 326 - 332
• Main Authors: Chen, Wen-Ling, Chen, Lung-Ching, Hsu, Pei-Sung, Shyu, Kou-GI, Hung, Huei-Fong, Lee, Shih-Huang, Wang, Tzu-Lin, Lai, Wei-Ting, Chen, Kuan-Jen, Liao, Zhen-Yu, Chuang, Cheng-Yen, Chou, Ching-Yao, Chua, Su-Kiat
• Format: Journal Article
• Language: English
• Published: Singapore Elsevier B.V 01.04.2025; Elsevier
• Subjects: Aged; Cardiac Pacing, Artificial - methods; Cardiopulmonary exercise testing; Chronotropic incompetence; Closed-loop stimulation; Cross-Over Studies; Exercise Test; Exercise Tolerance; Female; Force vital capacity; Heart Rate; Humans; Lung - physiopathology; Male; Middle Aged; Oxygen Consumption; Pacemaker, Artificial; Peak oxygen uptake; Spirometry; Vital Capacity; Peak oxygen uptake; Force vital capacity; Cardiopulmonary exercise testing; Closed-loop stimulation; Chronotropic incompetence

Chronotropic incompetence (CI) severely limits exercise tolerance due to impaired heart rate responses. This study investigated whether pacemaker with closed-loop stimulation (DDD-CLS) pacing, which provides rate acceleration in response to exertion, could enhance lung function and cardiopulmonary c...