Assessing the potential of NS2B/NS3 protease inhibitors biomarker in curbing dengue virus infections: In silico vs. In vitro approach

• Published in: Frontiers in cellular and infection microbiology Vol. 13; p. 1061937
• Main Authors: Norshidah, Harun, Leow, Chiuan Herng, Ezleen, Kamarulzaman Ezatul, Wahab, Habibah A., Vignesh, Ramachandran, Rasul, Azhar, Lai, Ngit Shin
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 14.02.2023
• Subjects: antiviral; Antiviral Agents - pharmacology; Antiviral Agents - therapeutic use; Biomarkers; Cellular and Infection Microbiology; Dengue - drug therapy; dengue virus; diagnostics; drug discovery; Humans; Molecular Targeted Therapy; NS2B/NS3pro; Protease Inhibitors - pharmacology; diagnostics; NS2B/NS3pro; drug discovery; antiviral; dengue virus

An increase in the occurrence of viral infectious diseases is a global concern for human health. According to a WHO report, dengue virus (DENV) is one of the most common viral diseases affecting approximately 400 million people annually, with worsening symptoms in nearly 1% of cases. Both academic a...