Induced Pluripotent Stem Cell Model of Pulmonary Arterial Hypertension Reveals Novel Gene Expression and Patient Specificity

• Published in: American journal of respiratory and critical care medicine Vol. 195; no. 7; pp. 930 - 941
• Main Authors: Sa, Silin, Gu, Mingxia, Chappell, James, Shao, Ning-Yi, Ameen, Mohamed, Elliott, Kathryn A. T., Li, Dan, Grubert, Fabian, Li, Caiyun G., Taylor, Shalina, Cao, Aiqin, Ma, Yu, Fong, Ryan, Nguyen, Long, Wu, Joseph C., Snyder, Michael P., Rabinovitch, Marlene
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.04.2017
• Subjects: Adolescent; Adult; Bone Morphogenetic Protein Receptors, Type II - genetics; Cell Differentiation - genetics; Cells, Cultured; Endothelial Cells - physiology; Female; Gene Expression - genetics; Humans; Hypertension, Pulmonary - genetics; Hypertension, Pulmonary - physiopathology; Induced Pluripotent Stem Cells; Male; Middle Aged; Original; Sensitivity and Specificity; Signal Transduction - genetics; KISS1; precision medicine; endothelial cells; SLIT3; CES1

Idiopathic or heritable pulmonary arterial hypertension is characterized by loss and obliteration of lung vasculature. Endothelial cell dysfunction is pivotal to the pathophysiology, but different causal mechanisms may reflect a need for patient-tailored therapies. Endothelial cells differentiated f...