Hypermethylation of Smad7 in CD4+ T cells is associated with the disease activity of rheumatoid arthritis

• Published in: Frontiers in immunology Vol. 14; p. 1104881
• Main Authors: Hu, Yiping, Xu, Bihua, He, Juan, Shan, Hongying, Zhou, Gengmin, Wang, Deli, Bai, Lu, Shang, Hongxi, Nie, Liping, Pan, Fan, Lan, Hui Yao, Wang, Qingwen
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 09.02.2023
• Subjects: Animals; Arthritis, Rheumatoid - drug therapy; CD4-Positive T-Lymphocytes - immunology; DNA - therapeutic use; DNA Methylation; DNA methyltransferase; hypermethylation; Immunology; Interleukin-6 - genetics; methyl-CpG binding domain; Mice; rheumatoid arthritis; Smad7; T-Lymphocytes, Regulatory; DNA methyltransferase; rheumatoid arthritis; Smad7; methyl-CpG binding domain; hypermethylation

Smad7 is protective in a mouse model of rheumatoid arthritis. Here we investigated whether Smad7-expressing CD4 T cells and the methylation of gene in CD4 T cells contribute to the disease activity of RA in patients. Peripheral CD4 T cells were collected from 35 healthy controls and 57 RA patients....