Low normal thyroid function enhances plasma cholesteryl ester transfer in Type 2 diabetes mellitus

• Published in: Atherosclerosis Vol. 228; no. 2; pp. 466 - 471
• Main Authors: Triolo, Michela, Kwakernaak, Arjan J, Perton, Frank G, de Vries, Rindert, Dallinga-Thie, Geesje M, Dullaart, Robin P.F
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.06.2013
• Subjects: Aged; atherosclerosis; Biomarkers - blood; blood glucose; Blood Glucose - analysis; body mass index; Cardiovascular; Case-Control Studies; Chi-Square Distribution; cholesterol; Cholesterol Ester Transfer Proteins - blood; Cholesteryl ester transfer; Cholesteryl ester transfer protein; cholesteryl esters; correlation; Cross-Sectional Studies; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - physiopathology; Euthyroidism; Female; Glycated Hemoglobin A - analysis; high density lipoprotein; Humans; hyperglycemia; Linear Models; low density lipoprotein; Male; metabolism; Middle Aged; Multivariate Analysis; noninsulin-dependent diabetes mellitus; Predictive Value of Tests; Reference Values; regression analysis; thyroid function; Thyroid Function Tests; Thyroid Gland - metabolism; Thyroid Gland - physiopathology; Thyroid-stimulating hormone; thyrotropin; Thyrotropin - blood; thyroxine; Thyroxine - blood; triacylglycerols; Triglycerides; Triglycerides - blood; Type 2 diabetes mellitus; Up-Regulation; Thyroid-stimulating hormone; Triglycerides; Type 2 diabetes mellitus; Cholesteryl ester transfer; Euthyroidism; Cholesteryl ester transfer protein

Abstract Background Plasma cholesteryl ester transfer (CET), reflecting endogenous transfer of cholesteryl esters from HDL to very low and low density lipoproteins, is elevated in Type 2 diabetes mellitus (T2DM), and may predict (subclinical) cardiovascular disease. Low normal thyroid function may a...