Is there need to search for alternatives to indomethacin for hemicrania continua? Case reports and a review

Abstract Hemicrania continua (HC) is a daily continuous unilateral headache of moderate intensity with super imposed exacerbations of more severe pain accompanied by migrainous and cranial autonomic features. Response to indomethacin is an essential feature in the IHS diagnostic criteria. However, i...

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Published inJournal of the neurological sciences Vol. 277; no. 1; pp. 187 - 190
Main Authors Prakash, Sanjay, Husain, Mahammed, Sureka, Dhara S, Shah, Nimish P, Shah, Nilima D
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 15.02.2009
Elsevier
Subjects
Adult
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Anticonvulsants - therapeutic use
Autonomic nervous system
Biological and medical sciences
Fructose - analogs & derivatives
Fructose - therapeutic use
Headache Disorders - drug therapy
Hemicrania continua
Humans
Idomethacin responsive headaches
Indomethacin - therapeutic use
Indomethacin and side effects
Male
Medical sciences
Middle Aged
Neurology
Tumors of the nervous system. Phacomatoses
Indomethacin and side effects
Idomethacin responsive headaches
Hemicrania continua
Case study
Nervous system diseases
Indometacin
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Abstract Abstract Hemicrania continua (HC) is a daily continuous unilateral headache of moderate intensity with super imposed exacerbations of more severe pain accompanied by migrainous and cranial autonomic features. Response to indomethacin is an essential feature in the IHS diagnostic criteria. However, indomethacin is associated with a number of side effects. HC is a life long condition, and skipping of a single dose of indomethacin usually leads to reappearance of headache. Various drugs have been tried as alternatives to indomethacin in the patients intolerant to indomethacin. We report two cases of HC responsive to topiramate and review the available alternatives for the patients of HC. We also discuss the side effects of indomethacin in the various headache disorders and other painful conditions, and suggest the need for trial of other drugs for the patients of HC.
AbstractList Hemicrania continua (HC) is a daily continuous unilateral headache of moderate intensity with super imposed exacerbations of more severe pain accompanied by migrainous and cranial autonomic features. Response to indomethacin is an essential feature in the IHS diagnostic criteria. However, indomethacin is associated with a number of side effects. HC is a life long condition, and skipping of a single dose of indomethacin usually leads to reappearance of headache. Various drugs have been tried as alternatives to indomethacin in the patients intolerant to indomethacin. We report two cases of HC responsive to topiramate and review the available alternatives for the patients of HC. We also discuss the side effects of indomethacin in the various headache disorders and other painful conditions, and suggest the need for trial of other drugs for the patients of HC.
Abstract Hemicrania continua (HC) is a daily continuous unilateral headache of moderate intensity with super imposed exacerbations of more severe pain accompanied by migrainous and cranial autonomic features. Response to indomethacin is an essential feature in the IHS diagnostic criteria. However, indomethacin is associated with a number of side effects. HC is a life long condition, and skipping of a single dose of indomethacin usually leads to reappearance of headache. Various drugs have been tried as alternatives to indomethacin in the patients intolerant to indomethacin. We report two cases of HC responsive to topiramate and review the available alternatives for the patients of HC. We also discuss the side effects of indomethacin in the various headache disorders and other painful conditions, and suggest the need for trial of other drugs for the patients of HC.
Author Shah, Nilima D
Shah, Nimish P
Prakash, Sanjay
Husain, Mahammed
Sureka, Dhara S
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Keywords Indomethacin and side effects
Idomethacin responsive headaches
Hemicrania continua
Case study
Nervous system diseases
Indometacin
Language English
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Snippet Abstract Hemicrania continua (HC) is a daily continuous unilateral headache of moderate intensity with super imposed exacerbations of more severe pain...
Hemicrania continua (HC) is a daily continuous unilateral headache of moderate intensity with super imposed exacerbations of more severe pain accompanied by...
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SubjectTerms Adult
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Anticonvulsants - therapeutic use
Autonomic nervous system
Biological and medical sciences
Fructose - analogs & derivatives
Fructose - therapeutic use
Headache Disorders - drug therapy
Hemicrania continua
Humans
Idomethacin responsive headaches
Indomethacin - therapeutic use
Indomethacin and side effects
Male
Medical sciences
Middle Aged
Neurology
Tumors of the nervous system. Phacomatoses
Title Is there need to search for alternatives to indomethacin for hemicrania continua? Case reports and a review
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https://dx.doi.org/10.1016/j.jns.2008.10.027
https://www.ncbi.nlm.nih.gov/pubmed/19041987
https://search.proquest.com/docview/66830449
https://search.proquest.com/docview/883036440
Volume 277
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