Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease

• Published in: Cell metabolism Vol. 30; no. 4; pp. 656 - 673
• Main Authors: Mori, Marcelo A., Ludwig, Raissa G., Garcia-Martin, Ruben, Brandão, Bruna B., Kahn, C. Ronald
• Format: Journal Article
• Language: English
• Published: United States 01.10.2019
• Subjects: Adipose Tissue - metabolism; Animals; Biomarkers - analysis; Biomarkers - metabolism; Cell Communication; Cell Line; Exosomes - metabolism; Humans; Metabolic Diseases - drug therapy; Metabolic Diseases - metabolism; Mice; MicroRNAs - analysis; MicroRNAs - metabolism; Neurodegenerative Diseases - drug therapy; Neurodegenerative Diseases - metabolism; Rats; adipose tissue; miRNA; exosome; extracellular vesicle; tissue communication

miRNAs can be found in serum and other body fluids and serve as biomarkers for disease. More importantly, secreted miRNAs, especially those in extracellular vesicles (EVs) such as exosomes, may mediate paracrine and endocrine communication between different tissues and thus modulate gene expression...