Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report

• Published in: Journal of psychopharmacology (Oxford) Vol. 25; no. 1; p. 121
• Main Authors: Crippa, José Alexandre S, Derenusson, Guilherme Nogueira, Ferrari, Thiago Borduqui, Wichert-Ana, Lauro, Duran, Fábio L S, Martin-Santos, Rocio, Simões, Marcus Vinícius, Bhattacharyya, Sagnik, Fusar-Poli, Paolo, Atakan, Zerrin, Santos Filho, Alaor, Freitas-Ferrari, Maria Cecília, McGuire, Philip K, Zuardi, Antonio Waldo, Busatto, Geraldo F, Hallak, Jaime Eduardo Cecílio
• Format: Journal Article
• Language: English
• Published: United States 01.01.2011
• Subjects: Adult; Anti-Anxiety Agents - pharmacology; Anxiety - diagnostic imaging; Anxiety - physiopathology; Anxiety Disorders - diagnostic imaging; Anxiety Disorders - drug therapy; Anxiety Disorders - physiopathology; Brain - diagnostic imaging; Brain - drug effects; Brain - physiopathology; Cannabidiol - pharmacology; Cerebrovascular Circulation - drug effects; Cross-Over Studies; Double-Blind Method; Humans; Male; Placebos; Psychiatric Status Rating Scales; Regional Blood Flow - drug effects; Tomography, Emission-Computed, Single-Photon; Young Adult
• ISSN: 1461-7285
• DOI: 10.1177/0269881110379283

Animal and human studies indicate that cannabidiol (CBD), a major constituent of cannabis, has anxiolytic properties. However, no study to date has investigated the effects of this compound on human pathological anxiety and its underlying brain mechanisms. The aim of the present study was to investi...