Early effects of intrastriatal injections of quinolinic acid on microtubule-associated protein-2 and neuropeptides in rat basal ganglia

• Published in: Neuroscience Vol. 93; no. 3; pp. 843 - 853
• Main Authors: Bordelon, Y.M., Chesselet, M.-F.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.01.1999; Elsevier
• Subjects: Animals; Basal Ganglia - metabolism; Biological and medical sciences; Corpus Striatum - drug effects; Corpus Striatum - physiology; Cytoskeleton - drug effects; Cytoskeleton - ultrastructure; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Disease Models, Animal; DNA Damage; Efferent Pathways - drug effects; Efferent Pathways - metabolism; enkephalin; Enkephalins - genetics; Enkephalins - metabolism; Excitatory Amino Acid Agonists - administration & dosage; Excitatory Amino Acid Agonists - pharmacology; Excitatory Amino Acid Agonists - toxicity; excitotoxicity; Globus Pallidus - anatomy & histology; Huntington Disease - metabolism; Huntington's disease; Injections; Male; Medical sciences; Mice; Mice, Neurologic Mutants; Microtubule-Associated Proteins - metabolism; Nerve Tissue Proteins - metabolism; Neurology; Neurons - drug effects; Neurons - metabolism; Neurons - pathology; Quinolinic Acid - administration & dosage; Quinolinic Acid - pharmacology; Quinolinic Acid - toxicity; rat; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate - agonists; Receptors, N-Methyl-D-Aspartate - physiology; RNA, Messenger - metabolism; striatum; substance P; Substance P - genetics; Substance P - metabolism; enkephalin; MAP-2, microtubule-associated protein 2; striatum; rat; PPT, preprotachykinin; PPE, preproenkephalin; excitotoxicity; substance P; Huntington's disease; NGS, normal goat serum; NMDA, N-methyl- d-aspartate; KPBS, potassium phosphate-buffered saline; Animal model; Rat; Toxicity; Central nervous system; Enkephalin; Neuropeptide; Opioid peptide; Degenerative disease; Nervous system diseases; Substance P; Rodentia; Huntington disease; Basal ganglion; Gene expression; Cerebral disorder; Genetic disease; Vertebrata; Mammalia; Microtubule associated protein 2; Central nervous system disease; Neurotransmitter; Excitatory aminoacid; Tachykinin; Brain (vertebrata); Extrapyramidal syndrome

The long-term effects of intrastriatal injections of the agonist of N-methyl- d-aspartate receptors, quinolinic acid, have been extensively characterized. Much less is known, however, about the early molecular and neurochemical changes which occur within a few hours of the toxin injection. In the pr...