Photo-Enhanced Singlet Oxygen Generation of Prussian Blue-Based Nanocatalyst for Augmented Photodynamic Therapy
Therapeutic effects of photodynamic therapy (PDT) remain largely limited because of tumor hypoxia. Herein, we report safe and versatile nanocatalysts (NCs) for endogenous oxygen generation and imaging-guided enhanced PDT. The NCs (named as PSP) are prepared by coating Prussian blue (PB) with mesopor...
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| Published in | iScience Vol. 9; pp. 14 - 26 |
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| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Elsevier
30.11.2018
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| Abstract | Therapeutic effects of photodynamic therapy (PDT) remain largely limited because of tumor hypoxia. Herein, we report safe and versatile nanocatalysts (NCs) for endogenous oxygen generation and imaging-guided enhanced PDT. The NCs (named as PSP) are prepared by coating Prussian blue (PB) with mesoporous silica to load photosensitizer (zinc phthalocyanine, ZnPc), followed by the modification of polyethylene glycol chains. The inner PB not only acts like a catalase for hydrogen peroxide decomposition but also serves as a photothermal agent to increase the local temperature and then speed up the oxygen supply under near-infrared irradiation. The loaded ZnPc can immediately transform the formed oxygen to generate cytotoxic singlet oxygen upon the same laser irradiation due to the overlapped absorption between PB and ZnPc. Results indicate that the PSP-ZnPc (PSPZP) NCs could realize the photothermally controlled improvement of hypoxic condition in cancer cells and tumor tissues, therefore demonstrating enhanced cancer therapy by the incorporation of PDT and photothermal therapy. |
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| AbstractList | Therapeutic effects of photodynamic therapy (PDT) remain largely limited because of tumor hypoxia. Herein, we report safe and versatile nanocatalysts (NCs) for endogenous oxygen generation and imaging-guided enhanced PDT. The NCs (named as PSP) are prepared by coating Prussian blue (PB) with mesoporous silica to load photosensitizer (zinc phthalocyanine, ZnPc), followed by the modification of polyethylene glycol chains. The inner PB not only acts like a catalase for hydrogen peroxide decomposition but also serves as a photothermal agent to increase the local temperature and then speed up the oxygen supply under near-infrared irradiation. The loaded ZnPc can immediately transform the formed oxygen to generate cytotoxic singlet oxygen upon the same laser irradiation due to the overlapped absorption between PB and ZnPc. Results indicate that the PSP-ZnPc (PSPZP) NCs could realize the photothermally controlled improvement of hypoxic condition in cancer cells and tumor tissues, therefore demonstrating enhanced cancer therapy by the incorporation of PDT and photothermal therapy.Therapeutic effects of photodynamic therapy (PDT) remain largely limited because of tumor hypoxia. Herein, we report safe and versatile nanocatalysts (NCs) for endogenous oxygen generation and imaging-guided enhanced PDT. The NCs (named as PSP) are prepared by coating Prussian blue (PB) with mesoporous silica to load photosensitizer (zinc phthalocyanine, ZnPc), followed by the modification of polyethylene glycol chains. The inner PB not only acts like a catalase for hydrogen peroxide decomposition but also serves as a photothermal agent to increase the local temperature and then speed up the oxygen supply under near-infrared irradiation. The loaded ZnPc can immediately transform the formed oxygen to generate cytotoxic singlet oxygen upon the same laser irradiation due to the overlapped absorption between PB and ZnPc. Results indicate that the PSP-ZnPc (PSPZP) NCs could realize the photothermally controlled improvement of hypoxic condition in cancer cells and tumor tissues, therefore demonstrating enhanced cancer therapy by the incorporation of PDT and photothermal therapy. Therapeutic effects of photodynamic therapy (PDT) remain largely limited because of tumor hypoxia. Herein, we report safe and versatile nanocatalysts (NCs) for endogenous oxygen generation and imaging-guided enhanced PDT. The NCs (named as PSP) are prepared by coating Prussian blue (PB) with mesoporous silica to load photosensitizer (zinc phthalocyanine, ZnPc), followed by the modification of polyethylene glycol chains. The inner PB not only acts like a catalase for hydrogen peroxide decomposition but also serves as a photothermal agent to increase the local temperature and then speed up the oxygen supply under near-infrared irradiation. The loaded ZnPc can immediately transform the formed oxygen to generate cytotoxic singlet oxygen upon the same laser irradiation due to the overlapped absorption between PB and ZnPc. Results indicate that the PSP-ZnPc (PSPZP) NCs could realize the photothermally controlled improvement of hypoxic condition in cancer cells and tumor tissues, therefore demonstrating enhanced cancer therapy by the incorporation of PDT and photothermal therapy. : Drug Delivery System; Chemistry; Inorganic Chemistry; Catalysis; Biological Sciences Subject Areas: Drug Delivery System, Chemistry, Inorganic Chemistry, Catalysis, Biological Sciences Therapeutic effects of photodynamic therapy (PDT) remain largely limited because of tumor hypoxia. Herein, we report safe and versatile nanocatalysts (NCs) for endogenous oxygen generation and imaging-guided enhanced PDT. The NCs (named as PSP) are prepared by coating Prussian blue (PB) with mesoporous silica to load photosensitizer (zinc phthalocyanine, ZnPc), followed by the modification of polyethylene glycol chains. The inner PB not only acts like a catalase for hydrogen peroxide decomposition but also serves as a photothermal agent to increase the local temperature and then speed up the oxygen supply under near-infrared irradiation. The loaded ZnPc can immediately transform the formed oxygen to generate cytotoxic singlet oxygen upon the same laser irradiation due to the overlapped absorption between PB and ZnPc. Results indicate that the PSP-ZnPc (PSPZP) NCs could realize the photothermally controlled improvement of hypoxic condition in cancer cells and tumor tissues, therefore demonstrating enhanced cancer therapy by the incorporation of PDT and photothermal therapy. Therapeutic effects of photodynamic therapy (PDT) remain largely limited because of tumor hypoxia. Herein, we report safe and versatile nanocatalysts (NCs) for endogenous oxygen generation and imaging-guided enhanced PDT. The NCs (named as PSP) are prepared by coating Prussian blue (PB) with mesoporous silica to load photosensitizer (zinc phthalocyanine, ZnPc), followed by the modification of polyethylene glycol chains. The inner PB not only acts like a catalase for hydrogen peroxide decomposition but also serves as a photothermal agent to increase the local temperature and then speed up the oxygen supply under near-infrared irradiation. The loaded ZnPc can immediately transform the formed oxygen to generate cytotoxic singlet oxygen upon the same laser irradiation due to the overlapped absorption between PB and ZnPc. Results indicate that the PSP-ZnPc (PSPZP) NCs could realize the photothermally controlled improvement of hypoxic condition in cancer cells and tumor tissues, therefore demonstrating enhanced cancer therapy by the incorporation of PDT and photothermal therapy. • All compositions have been approved by the US Food and Drug Administration • PSP- 89 Zr serves as a dual-modal PET and PAI imaging agent • PSP shows catalase-like activity toward H 2 O 2 decomposition under tumor-microenvironment • Photo-enhanced endogenous O 2 generation of PSPZP for augmented photodynamic therapy Drug Delivery System; Chemistry; Inorganic Chemistry; Catalysis; Biological Sciences |
| Author | Wang, Dongdong Cai, Weibo Chen, Qianwang Wu, Huihui Wang, Hui Xia, Guoliang Guo, Zhen Shi, Ruohong Zhou, Jiajia Shi, Sixiang Barnhart, Todd E. Xu, Pengping |
| AuthorAffiliation | 1 Hefei National Laboratory for Physical Science at Microscale and Department of Materials Science & Engineering, University of Science & Technology of China, Hefei, Anhui 230026, PR China 4 The Anhui Key Laboratory of Condensed Matter Physics at Extreme Conditions, High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, PR China 3 Departments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, USA 2 Anhui Key Laboratory for Cellular Dynamics and Chemical Biology, School of Life Sciences, University of Science & Technology of China, Hefei, Anhui 230026, PR China |
| AuthorAffiliation_xml | – name: 2 Anhui Key Laboratory for Cellular Dynamics and Chemical Biology, School of Life Sciences, University of Science & Technology of China, Hefei, Anhui 230026, PR China – name: 3 Departments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, USA – name: 4 The Anhui Key Laboratory of Condensed Matter Physics at Extreme Conditions, High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, PR China – name: 1 Hefei National Laboratory for Physical Science at Microscale and Department of Materials Science & Engineering, University of Science & Technology of China, Hefei, Anhui 230026, PR China |
| Author_xml | – sequence: 1 givenname: Dongdong orcidid: 0000-0002-6278-0706 surname: Wang fullname: Wang, Dongdong – sequence: 2 givenname: Ruohong surname: Shi fullname: Shi, Ruohong – sequence: 3 givenname: Jiajia surname: Zhou fullname: Zhou, Jiajia – sequence: 4 givenname: Sixiang surname: Shi fullname: Shi, Sixiang – sequence: 5 givenname: Huihui surname: Wu fullname: Wu, Huihui – sequence: 6 givenname: Pengping surname: Xu fullname: Xu, Pengping – sequence: 7 givenname: Hui surname: Wang fullname: Wang, Hui – sequence: 8 givenname: Guoliang surname: Xia fullname: Xia, Guoliang – sequence: 9 givenname: Todd E. surname: Barnhart fullname: Barnhart, Todd E. – sequence: 10 givenname: Weibo surname: Cai fullname: Cai, Weibo – sequence: 11 givenname: Zhen surname: Guo fullname: Guo, Zhen – sequence: 12 givenname: Qianwang surname: Chen fullname: Chen, Qianwang |
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| Snippet | Therapeutic effects of photodynamic therapy (PDT) remain largely limited because of tumor hypoxia. Herein, we report safe and versatile nanocatalysts (NCs) for... |
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| Title | Photo-Enhanced Singlet Oxygen Generation of Prussian Blue-Based Nanocatalyst for Augmented Photodynamic Therapy |
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