Severe atopic dermatitis is characterized by selective expansion of circulating TH2/TC2 and TH22/TC22, but not TH17/TC17, cells within the skin-homing T-cell population

• Published in: Journal of allergy and clinical immunology Vol. 136; no. 1; pp. 104 - 115.e7
• Main Authors: Czarnowicki, Tali, Gonzalez, Juana, Shemer, Avner, Malajian, Dana, Xu, Hui, Zheng, Xiuzhong, Khattri, Saakshi, Gilleaudeau, Patricia, Sullivan-Whalen, Mary, Suárez-Fariñas, Mayte, Krueger, James G., Guttman-Yassky, Emma
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2015; Elsevier Limited
• Subjects: Adolescent; Adult; Age; Aged; Alzheimer's disease; Antigens, Differentiation, T-Lymphocyte - metabolism; Atopic dermatitis; CD8-Positive T-Lymphocytes - immunology; Cell Movement; Cells, Cultured; cutaneous lymphocyte antigen; Cytokines; Dementia; Dermatitis, Atopic - immunology; Disease Progression; Expansion; Female; Humans; IFN-γ; IL-13; IL-22; Immunophenotyping; Interleukin-17 - metabolism; Interleukin-22; Interleukins - metabolism; Lymphocytes; Male; Membrane Glycoproteins - metabolism; Middle Aged; Population; Skin - immunology; skin infections; Staphylococcus infections; Studies; T cell; T-Lymphocyte Subsets - immunology; Th17 Cells - immunology; Th2 Cells - immunology; Young Adult; MFI; IFN-γ; AD; Atopic dermatitis; cutaneous lymphocyte antigen; PMA; T cell; skin infections; ICS; CLA; IL-13; IL-22

Past studies of blood T-cell phenotyping in patients with atopic dermatitis (AD) have provided controversial results and were mostly performed before the identification of TH9, TH17, and TH22 T-cell populations in human subjects. We sought to quantify TH1, TH2, TH9, TH17, and TH22 T-cell populations...