Tanshinone IIA alleviates cardiac hypertrophy through m6A modification of galectin-3

• Published in: Bioengineered Vol. 13; no. 2; pp. 4260 - 4270
• Main Authors: Zhang, Meiqi, Chen, Yun, Chen, Huan, Shen, Ye, Pang, Lingxiao, Wu, Weihua, Yu, Zhenfei
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.02.2022
• Subjects: Abietanes - administration & dosage; alkB homolog 5; Animals; cardiac hypertrophy; Cardiomegaly - drug therapy; Cardiomegaly - genetics; Cardiomegaly - metabolism; Drugs, Chinese Herbal - administration & dosage; Galectin 3 - genetics; Galectin 3 - metabolism; galectin-3; Humans; Male; Methylation; Mice; Mice, Inbred C57BL; N6-methyladenosine; Research Paper; RNA demethylase; Salvia miltiorrhiza - chemistry; Signal Transduction; Tanshinone IIA; Tanshinone IIA; alkB homolog 5; N6-methyladenosine; RNA demethylase; cardiac hypertrophy; galectin-3

Cardiac hypertrophy results from the adaptive response of the myocardium to pressure overload on the heart. Tanshinone IIA (Tan IIA) is the major active compound extracted from Salvia miltiorrhiza Bunge, which possesses various pharmacological benefits. In the present study, the effect and mechanism...