Endothelial colony-forming cell-derived exosomal miR-21-5p regulates autophagic flux to promote vascular endothelial repair by inhibiting SIPL1A2 in atherosclerosis

• Published in: Cell communication and signaling Vol. 20; no. 1; pp. 30 - 21
• Main Authors: Ke, Xiao, Liao, Zhiyong, Luo, Xinlin, Chen, Jun-qiu, Deng, Ming, Huang, Yiteng, Wang, Zanxin, Wei, Minxin
• Format: Journal Article
• Language: English
• Published: England BioMed Central 12.03.2022; BMC
• Subjects: Animals; Apoptosis; Atherosclerosis; Atherosclerosis - metabolism; Autophagic flux; Autophagy; Cells, Cultured; Endothelial Cells - metabolism; Endothelial progenitor cell-derived exosomes; Exosomes - metabolism; MicroRNAs - genetics; MicroRNAs - metabolism; miR-21-5p; Rats; SIPA1L2; Vascular System Injuries - metabolism; Endothelial progenitor cell-derived exosomes; SIPA1L2; miR-21-5p; Atherosclerosis; Autophagic flux

Percutaneous transluminal coronary angioplasty (PTCA) represents an efficient therapeutic method for atherosclerosis but conveys a risk of causing restenosis. Endothelial colony-forming cell-derived exosomes (ECFC-exosomes) are important mediators during vascular repair. This study aimed to investig...