Pan-cancer analysis identifies NT5E as a novel prognostic biomarker on cancer-associated fibroblasts associated with unique tumor microenvironment

• Published in: Frontiers in pharmacology Vol. 13; p. 1064032
• Main Authors: Xue, Xin-miao, Liu, Yu-yang, Chen, Xue-min, Tao, Bing-yan, Liu, Peng, Zhou, Han-wen, Zhang, Chi, Wang, Li, Jiang, Yu-ke, Ding, Zhi-wei, Shen, Wei-dong, Zhang, Jun, Yang, Shi-ming, Wang, Fang-yuan
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 07.12.2022
• Subjects: cancer-associated fibroblast; CD73; epithelial-mesenchymal transition; immunotherapy; NT5E; pan-cancer analysis; Pharmacology; cancer-associated fibroblast; CD73; NT5E; epithelial-mesenchymal transition; immunotherapy; pan-cancer analysis

Background: Ecto-5′-nucleotidase (NT5E) encodes the cluster of differentiation 73 (CD73), whose overexpression contributes to the formation of immunosuppressive tumor microenvironment and is related to exacerbated prognosis, increased risk of metastasis and resistance to immunotherapy of various tum...