Imeglimin lowers glucose primarily by amplifying glucose-stimulated insulin secretion in high-fat-fed rodents - Perry, Rachel J.; Cardone, Rebecca L.; Petersen, Max C.; Zhang, Dongyan; Fouqueray, Pascale; Hallakou-Bozec, Sophie; Bolze, Sébastien; Shulman, Gerald I.; Petersen, Kitt Falk; Kibbey, Richard G. (American journal of physiology: endocrinology and metabolism, 2016)
Keywords: Animals; Blood Glucose - drug effects; Blood Glucose - metabolism; Call for Papers; Diet, High-Fat; Fasting; Glucose - metabolism; Glucose Clamp Technique; Hypoglycemic Agents - pharmacology; Insulin - metabolism; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells - drug effects; Insulin-Secreting Cells - metabolism; Liver - drug effects; Liver - metabolism; Male; Mice; Mice, Inbred C57BL; Postprandial Period; Rats; Rats, Sprague-Dawley; Triazines - pharmacology; β-cell; imeglimin; glucose-stimulated insulin secretion