Augmentation therapy with minocycline in treatment-resistant depression patients with low-grade peripheral inflammation: results from a double-blind randomised clinical trial

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 46; no. 5; pp. 939 - 948
• Main Authors: Nettis, Maria Antonietta, Lombardo, Giulia, Hastings, Caitlin, Zajkowska, Zuzanna, Mariani, Nicole, Nikkheslat, Naghmeh, Worrell, Courtney, Enache, Daniela, McLaughlin, Anna, Kose, Melisa, Sforzini, Luca, Bogdanova, Anna, Cleare, Anthony, Young, Allan H., Pariante, Carmine M., Mondelli, Valeria
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.04.2021; Springer International Publishing
• Subjects: Adjuvant therapy; Antibiotics; Antidepressants; C-reactive protein; Clinical trials; Depression; Depressive Disorder, Treatment-Resistant - drug therapy; Double-Blind Method; Double-blind studies; Humans; Inflammation; Inflammation - drug therapy; Interleukin 6; Mental depression; Minocycline; Minocycline - therapeutic use; Patients; Placebos; Treatment Outcome; Treatment resistance; γ-Interferon

This study aimed to investigate the role of baseline levels of peripheral inflammation when testing the efficacy of antidepressant augmentation with minocycline in patients with treatment-resistant depression. We conducted a 4-week, placebo-controlled, randomised clinical trial of minocycline (200 m...