Translesion DNA polymerases in eukaryotes: what makes them tick?

• Published in: Critical reviews in biochemistry and molecular biology Vol. 52; no. 3; pp. 274 - 303
• Main Authors: Vaisman, Alexandra, Woodgate, Roger
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 04.05.2017
• Subjects: Animals; DNA Damage; DNA polymerase families; DNA Repair - physiology; DNA Replication - physiology; DNA-Directed DNA Polymerase - genetics; DNA-Directed DNA Polymerase - metabolism; Humans; mutagenesis; PCNA; protein interaction network; replicative bypass; Translesion synthesis; ubiquitin; PCNA; protein interaction network; DNA polymerase families; Translesion synthesis; mutagenesis; replicative bypass; ubiquitin

Life as we know it, simply would not exist without DNA replication. All living organisms utilize a complex machinery to duplicate their genomes and the central role in this machinery belongs to replicative DNA polymerases, enzymes that are specifically designed to copy DNA. "Hassle-free" D...