Dental calculus: A repository of bioinformation indicating diseases and human evolution

Dental calculus has long been considered as a vital contributing factor of periodontal diseases. Our review focuses on the role of dental calculus as a repository and discusses the bioinformation recently reported to be concealed in dental calculus from three perspectives: time-varying oral conditio...

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Published inFrontiers in cellular and infection microbiology Vol. 12; p. 1035324
Main Authors Li, Qinyang, Luo, Kaihua, Su, Zhifei, Huang, Fangting, Wu, Yajie, Zhou, Fangjie, Li, Yuqing, Peng, Xian, Li, Jiyao, Ren, Biao
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 12.12.2022
Subjects
anthropology
Bacteria - genetics
bioinformation
Cellular and Infection Microbiology
Dental Calculus
disease
Humans
microbiome
Microbiota
Periodontal Diseases - microbiology
dental calculus
anthropology
disease
microbiome
bioinformation
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Abstract Dental calculus has long been considered as a vital contributing factor of periodontal diseases. Our review focuses on the role of dental calculus as a repository and discusses the bioinformation recently reported to be concealed in dental calculus from three perspectives: time-varying oral condition, systemic diseases, and anthropology at various times. Molecular information representing an individual's contemporary oral health status could be detected in dental calculus. Additionally, pathogenic factors of systemic diseases were found in dental calculus, including bacteria, viruses and toxic heavy metals. Thus, dental calculus has been proposed to play a role as biological data storage for detection of molecular markers of latent health concerns. Through the study of environmental debris in dental calculus, an overview of an individual's historical dietary habits and information about the environment, individual behaviors and social culture changes can be unveiled. This review summarizes a new role of dental calculus as a repository of bioinformation, with potential use in the prediction of oral diseases, systemic diseases, and even anthropology.
AbstractList Dental calculus has long been considered as a vital contributing factor of periodontal diseases. Our review focuses on the role of dental calculus as a repository and discusses the bioinformation recently reported to be concealed in dental calculus from three perspectives: time-varying oral condition, systemic diseases, and anthropology at various times. Molecular information representing an individual’s contemporary oral health status could be detected in dental calculus. Additionally, pathogenic factors of systemic diseases were found in dental calculus, including bacteria, viruses and toxic heavy metals. Thus, dental calculus has been proposed to play a role as biological data storage for detection of molecular markers of latent health concerns. Through the study of environmental debris in dental calculus, an overview of an individual’s historical dietary habits and information about the environment, individual behaviors and social culture changes can be unveiled. This review summarizes a new role of dental calculus as a repository of bioinformation, with potential use in the prediction of oral diseases, systemic diseases, and even anthropology.
Author Wu, Yajie
Li, Yuqing
Ren, Biao
Su, Zhifei
Huang, Fangting
Peng, Xian
Li, Jiyao
Luo, Kaihua
Zhou, Fangjie
Li, Qinyang
AuthorAffiliation 2 State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University , Chengdu , China
1 State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University , Chengdu , China
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Keywords dental calculus
anthropology
disease
microbiome
bioinformation
Language English
License Copyright © 2022 Li, Luo, Su, Huang, Wu, Zhou, Li, Peng, Li and Ren.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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Notes Reviewed by: Sterling Wright, The Pennsylvania State University (PSU), United States; Keke Zhang, Wenzhou Medical University, China; Jin Xiao, University of Rochester Medical Center, United States
This article was submitted to Bacteria and Host, a section of the journal Frontiers in Cellular and Infection Microbiology
Edited by: Zhengwei Huang, Shanghai Jiao Tong University, China
These authors have contributed equally to this work
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Snippet Dental calculus has long been considered as a vital contributing factor of periodontal diseases. Our review focuses on the role of dental calculus as a...
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StartPage 1035324
SubjectTerms anthropology
Bacteria - genetics
bioinformation
Cellular and Infection Microbiology
Dental Calculus
disease
Humans
microbiome
Microbiota
Periodontal Diseases - microbiology
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Title Dental calculus: A repository of bioinformation indicating diseases and human evolution
URI https://www.ncbi.nlm.nih.gov/pubmed/36579339
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