Integrative metabolic analysis of orbital adipose/connective tissue in patients with thyroid-associated ophthalmopathy

• Published in: Frontiers in endocrinology (Lausanne) Vol. 13; p. 1001349
• Main Authors: Huang, Jiancheng, Chen, Meng, Liang, Yu, Hu, Yuxiang, Xia, Weiyi, Zhang, Yihan, Zhao, Chen, Wu, Lianqun
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 18.11.2022
• Subjects: Adipose Tissue; Autoimmune Diseases; Cholesterol; cholesterol metabolism; Endocrinology; Endoribonucleases; Graves Ophthalmopathy - genetics; Humans; LC-MS; metabolic profile; orbital adipose/connective tissue; Protein Serine-Threonine Kinases; thyroid-associated ophthalmopathy; LC-MS; orbital adipose/connective tissue; thyroid-associated ophthalmopathy; cholesterol metabolism; metabolic profile

Thyroid-associated ophthalmopathy (TAO) is a disfiguring autoimmune disease, which destroys the structure of orbital tissues and even threatens vision. Metabolic reprograming is critical in autoimmune diseases; however, the metabolic basis of TAO remains to be clarified. Our study aimed to reveal th...