The effects of dynamic compression on the development of cartilage grafts engineered using bone marrow and infrapatellar fat pad derived stem cells

• Published in: Biomedical materials (Bristol) Vol. 10; no. 5; pp. 55011 - 55022
• Main Authors: Luo, Lu, Thorpe, Stephen D, Buckley, Conor T, Kelly, Daniel J
• Format: Journal Article
• Language: English
• Published: England IOP Publishing 21.09.2015
• Subjects: Adipocytes - cytology; Adipocytes - physiology; Adipose Tissue - cytology; Adipose Tissue - physiology; agarose; Animals; bioreactor; Bioreactors; Cartilage; Cartilage - cytology; Cartilage - growth & development; Cells, Cultured; Chondrogenesis - physiology; Coculture Techniques - methods; Compressing; Compressive Strength - physiology; Construction; Dynamics; Filled plastics; Grafts; Mechanotransduction, Cellular - physiology; Mesenchymal Stromal Cells - cytology; Mesenchymal Stromal Cells - physiology; Patella - cytology; Patella - physiology; Physical Stimulation - methods; stem cell; Stem cells; Stress, Mechanical; Surgical implants; Swine; tissue engineering; Tissue Engineering - methods

Bioreactors that subject cell seeded scaffolds or hydrogels to biophysical stimulation have been used to improve the functionality of tissue engineered cartilage and to explore how such constructs might respond to the application of joint specific mechanical loading. Whether a particular cell type r...