Investigation of associations between exposures to pesticides and testosterone levels in Thai farmers

We conducted a cross-sectional study to assess the relationship between pesticide exposures and testosterone levels in 133 male Thai farmers. Urine and serum samples were collected concurrently from participants. Urine was analyzed for levels of specific and nonspecific metabolites of organophosphat...

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Bibliographic Details
Published inArchives of environmental & occupational health Vol. 73; no. 4; pp. 205 - 218
Main Authors Panuwet, Parinya, Ladva, Chandresh, Barr, Dana Boyd, Prapamontol, Tippawan, Meeker, John D., D'Souza, Priya Esilda, Maldonado, Héctor, Ryan, P. Barry, Robson, Mark G.
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 04.07.2018
Subjects
Adult
Chromatography, Gas
Chromatography, High Pressure Liquid
Cross-Sectional Studies
Endocrine disruptor
exposures
farmers
Farmers - statistics & numerical data
Fungicides, Industrial - urine
Gas Chromatography-Mass Spectrometry
Herbicides - urine
Humans
Insecticides - urine
Male
Middle Aged
Occupational Exposure - analysis
Organophosphates - urine
pesticides
Pyrethrins - urine
reproductive health
Tandem Mass Spectrometry
testosterone
Testosterone - blood
Thailand
Young Adult
Thailand
exposures
Endocrine disruptor
farmers
testosterone
pesticides
reproductive health
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Summary:We conducted a cross-sectional study to assess the relationship between pesticide exposures and testosterone levels in 133 male Thai farmers. Urine and serum samples were collected concurrently from participants. Urine was analyzed for levels of specific and nonspecific metabolites of organophosphates (OPs), pyrethroids, select herbicides, and fungicides. Serum was analyzed for total and free testosterone. Linear regression analyses revealed significant negative relationships between total testosterone and the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) after controlling for covariates (eg, age, BMI, smoking status). Positive significant associations were found between some OP pesticides and total testosterone. Due to the small sample size and the observational nature of the study, future investigation is needed to confirm our results and to elucidate the biological mechanisms.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1933-8244
2154-4700
DOI:10.1080/19338244.2017.1378606