Nonhuman primates as models for the discovery and development of radiation countermeasures

• Published in: Expert opinion on drug discovery Vol. 12; no. 7; pp. 695 - 709
• Main Authors: Singh, Vijay K., Olabisi, Ayodele O.
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 03.07.2017
• Subjects: Acute radiation syndrome; Acute Radiation Syndrome - prevention & control; animal model; Animals; Disease Models, Animal; Drug Approval; Drug Design; Drug Discovery - methods; FDA animal rule; Humans; Macaca mulatta; macaques; nonhuman primates; Primates; radiation countermeasures; Radiation-Protective Agents - adverse effects; Radiation-Protective Agents - therapeutic use; rhesus; United States; United States Food and Drug Administration; rhesus; Acute radiation syndrome; FDA animal rule; nonhuman primates; animal model; macaques; radiation countermeasures

Introduction: Despite significant scientific advances over the past six decades toward the development of safe and effective radiation countermeasures for humans using animal models, only two pharmaceutical agents have been approved by United States Food and Drug Administration (US FDA) for hematopo...