Semaphorin 4C Protects against Allergic Inflammation: Requirement of Regulatory CD138+ Plasma Cells

• Published in: The Journal of immunology (1950) Vol. 198; no. 1; pp. 71 - 81
• Main Authors: Xue, Di, Kaufman, Gabriel N, Dembele, Marieme, Beland, Marianne, Massoud, Amir H, Mindt, Barbara C, Fiter, Ryan, Fixman, Elizabeth D, Martin, James G, Friedel, Roland H, Divangahi, Maziar, Fritz, Jörg H, Mazer, Bruce D
• Format: Journal Article
• Language: English
• Published: United States American Association of Immunologists 01.01.2017
• Subjects: Adoptive Transfer; Allergens; Allergic diseases; Alveoli; Animals; Autoimmune diseases; Axon guidance; B-Lymphocyte Subsets - immunology; Blotting, Western; Bone marrow; Bronchus; CD19 antigen; Cytokines; Cytokines - biosynthesis; Eosinophilia; Flight corridors; Flow Cytometry; Homeostasis; Hypersensitivity; Immune response; Immunoregulation; Inflammation; Interleukin 10; Interleukin 4; Interleukin 5; Leukocytes (eosinophilic); Lung diseases; Lungs; Lymphocyte receptors; Lymphocytes; Lymphocytes B; Lymphocytes T; Mice; Mice, Inbred C57BL; Mice, Knockout; Plasma cells; Plasma Cells - immunology; Pneumonia - immunology; Respiratory Hypersensitivity - immunology; Respiratory tract; Respiratory tract diseases; Semaphorins - immunology; Syndecan-1 - immunology; T cell receptors

The regulatory properties of B cells have been studied in autoimmune diseases; however, their role in allergic diseases is poorly understood. We demonstrate that Semaphorin 4C (Sema4C), an axonal guidance molecule, plays a crucial role in B cell regulatory function. Mice deficient in Sema4C exhibite...