A-910823, a squalene-based emulsion adjuvant, induces T follicular helper cells and humoral immune responses via α-tocopherol component

• Published in: Frontiers in immunology Vol. 14; p. 1116238
• Main Authors: Yoshioka, Yuya, Kobiyama, Kouji, Hayashi, Tomoya, Onishi, Motoyasu, Yanagida, Yosuke, Nakagawa, Takayuki, Hashimoto, Masayuki, Nishinaka, Anri, Hirose, Jun, Asaoka, Yoshiji, Tajiri, Minako, Hayata, Atsushi, Ishida, Satoru, Omoto, Shinya, Nagira, Morio, Ishii, Ken J.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 20.02.2023
• Subjects: A-910823; adjuvant; Adjuvants, Immunologic - pharmacology; Adjuvants, Pharmaceutic; alpha-Tocopherol - pharmacology; Animals; COVID-19; Emulsions; Humans; Immunity, Humoral; Immunology; Mice; mouse; S-268019-b; SARS-CoV-2; Squalene - pharmacology; T Follicular Helper Cells; Tfh; vaccine; mouse; vaccine; adjuvant; immune response; severe acute respiratory syndrome coronavirus 2; Tfh; S-268019-b; A-910823

Adjuvants are chemical or biological materials that enhance the efficacy of vaccines. A-910823 is a squalene-based emulsion adjuvant used for S-268019-b, a novel vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that is currently in clinical development. Published evidence...