GPR30-mediated non-classic estrogen pathway in mast cells participates in endometriosis pain via the production of FGF2

• Published in: Frontiers in immunology Vol. 14; p. 1106771
• Main Authors: Xu, Xinxin, Wang, Jianzhang, Guo, Xinyue, Chen, Yichen, Ding, Shaojie, Zou, Gen, Zhu, Libo, Li, Tiantian, Zhang, Xinmei
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 08.02.2023
• Subjects: Animals; endometriosis; Endometriosis - pathology; Estrogens - pharmacology; Female; Fibroblast Growth Factor 2; G-protein coupled receptor 30; Humans; Immunology; mast cell; Mast Cells - metabolism; Ovarian Neoplasms - pathology; pain; Pain Threshold; Rats; Receptors, Estrogen; G-protein coupled receptor 30; endometriosis; mast cell; pain; fibroblast growth factor 2

Pain is one of the main clinical symptoms of endometriosis, but its underlying mechanism is still not clear. Recent studies have shown that the secretory mediators of mast cells activated by estrogen are involved in the pathogenesis of endometriosis-related pain, but how estrogen-induced mast cell m...