Continuous ZnO nanoparticle exposure induces melanoma-like skin lesions in epidermal barrier dysfunction model mice through anti-apoptotic effects mediated by the oxidative stress–activated NF-κB pathway

• Published in: Journal of nanobiotechnology Vol. 20; no. 1; pp. 111 - 23
• Main Authors: Wang, Ping, Hu, Guodong, Zhao, Wen, Du, Juan, You, Menghan, Xv, Mengying, Yang, Hong, Zhang, Min, Yan, Fang, Huang, Mianbo, Wang, Xueer, Zhang, Lin, Chen, Yinghua
• Format: Journal Article
• Language: English
• Published: England BioMed Central 05.03.2022; BMC
• Subjects: Animals; Anti-apoptosis; Apoptosis; Epidermal barrier dysfunction skin; Epidermis - metabolism; Melanocyte; Melanoma - drug therapy; Melanoma - metabolism; Mice; Nanoparticles - toxicity; NF-kappa B - metabolism; NF-κB p65; Oxidative Stress; Reactive Oxygen Species - metabolism; Zinc Oxide - pharmacology; Zinc oxide nanoparticles; Oxidative stress; Epidermal barrier dysfunction skin; Anti-apoptosis; NF-κB p65; Melanocyte; Zinc oxide nanoparticles

Increasing interest in the hazardous properties of zinc oxide nanoparticles (ZnO NPs), commonly used as ultraviolet filters in sunscreen, has driven efforts to study the percutaneous application of ZnO NPs to diseased skin; however, in-depth studies of toxic effects on melanocytes under conditions o...