Cyanidin-3-o-glucoside (C3G) inhibits vascular leakage regulated by microglial activation in early diabetic retinopathy and neovascularization in advanced diabetic retinopathy
Cyanidin-3-O-glucoside (C3G) is a kind of anthocyanin which shows strong anti-inflammation, anti-tumor and anti-oxidant properties. This paper was designed to explore the potential effects of C3G on diabetic retinopathy (DR). C57BL/6 mice were administrated with streptozotocin (STZ) or vehicle contr...
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Published in | Bioengineered Vol. 12; no. 2; pp. 9266 - 9278 |
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20.12.2021
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Abstract | Cyanidin-3-O-glucoside (C3G) is a kind of anthocyanin which shows strong anti-inflammation, anti-tumor and anti-oxidant properties. This paper was designed to explore the potential effects of C3G on diabetic retinopathy (DR). C57BL/6 mice were administrated with streptozotocin (STZ) or vehicle control for the establishment of diabetic models. To simulate hyperglycemia and hypoxia, D-glucose (30 mM) and CoCl
2
(200 μm/l) were utilized to treat HRECs, respectively. The migration, invasion, inflammation and tube formation abilities of cells were evaluated with the adoption of wound healing, transwell, ELISA and tube formation assays, respectively. Besides, immunofluorescence staining was utilized to detect proliferation and retinal vessels. Evans blue permeation assay were performed to evaluate the vascular leakage in DR mice. Moreover, western blot and qPCR were used to quantify the mRNA and protein expressions of ionized calcium-binding adapter molecule (Iba)-1 and tight junction proteins. Results showed that C3G alleviated the inflammation, microglial activation and angiogenesis in DR mice. Moreover, the proliferation and inflammation of BV2 cells induced by high glucose (HG) were suppressed by C3G. Evans blue permeation assay demonstrated the potency of C3G in attenuating vascular leakage. In addition, C3G suppressed the migration, invasion and angiogenesis of human retinal endothelial cells (HRECs) DR model in vitro.
By confirming the role of C3G in inhibiting vascular leakage regulated by microglia activation in early DR and angiogenesis in advanced DR, this study pointed out the potential of C3G as a therapeutic drug for DR management. |
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AbstractList | Cyanidin-3-O-glucoside (C3G) is a kind of anthocyanin which shows strong anti-inflammation, anti-tumor and anti-oxidant properties. This paper was designed to explore the potential effects of C3G on diabetic retinopathy (DR). C57BL/6 mice were administrated with streptozotocin (STZ) or vehicle control for the establishment of diabetic models. To simulate hyperglycemia and hypoxia, D-glucose (30 mM) and CoCl
2
(200 μm/l) were utilized to treat HRECs, respectively. The migration, invasion, inflammation and tube formation abilities of cells were evaluated with the adoption of wound healing, transwell, ELISA and tube formation assays, respectively. Besides, immunofluorescence staining was utilized to detect proliferation and retinal vessels. Evans blue permeation assay were performed to evaluate the vascular leakage in DR mice. Moreover, western blot and qPCR were used to quantify the mRNA and protein expressions of ionized calcium-binding adapter molecule (Iba)-1 and tight junction proteins. Results showed that C3G alleviated the inflammation, microglial activation and angiogenesis in DR mice. Moreover, the proliferation and inflammation of BV2 cells induced by high glucose (HG) were suppressed by C3G. Evans blue permeation assay demonstrated the potency of C3G in attenuating vascular leakage. In addition, C3G suppressed the migration, invasion and angiogenesis of human retinal endothelial cells (HRECs) DR model in vitro.
By confirming the role of C3G in inhibiting vascular leakage regulated by microglia activation in early DR and angiogenesis in advanced DR, this study pointed out the potential of C3G as a therapeutic drug for DR management. Cyanidin-3-O-glucoside (C3G) is a kind of anthocyanin which shows strong anti-inflammation, anti-tumor and anti-oxidant properties. This paper was designed to explore the potential effects of C3G on diabetic retinopathy (DR). C57BL/6 mice were administrated with streptozotocin (STZ) or vehicle control for the establishment of diabetic models. To simulate hyperglycemia and hypoxia, D-glucose (30 mM) and CoCl (200 μm/l) were utilized to treat HRECs, respectively. The migration, invasion, inflammation and tube formation abilities of cells were evaluated with the adoption of wound healing, transwell, ELISA and tube formation assays, respectively. Besides, immunofluorescence staining was utilized to detect proliferation and retinal vessels. Evans blue permeation assay were performed to evaluate the vascular leakage in DR mice. Moreover, western blot and qPCR were used to quantify the mRNA and protein expressions of ionized calcium-binding adapter molecule (Iba)-1 and tight junction proteins. Results showed that C3G alleviated the inflammation, microglial activation and angiogenesis in DR mice. Moreover, the proliferation and inflammation of BV2 cells induced by high glucose (HG) were suppressed by C3G. Evans blue permeation assay demonstrated the potency of C3G in attenuating vascular leakage. In addition, C3G suppressed the migration, invasion and angiogenesis of human retinal endothelial cells (HRECs) DR model in vitro.By confirming the role of C3G in inhibiting vascular leakage regulated by microglia activation in early DR and angiogenesis in advanced DR, this study pointed out the potential of C3G as a therapeutic drug for DR management. |
Author | Zhao, Fangling Ge, XiaoJuan Gao, Xiang Cui, Jiawen Liu, Xia |
Author_xml | – sequence: 1 givenname: Fangling surname: Zhao fullname: Zhao, Fangling organization: Nantong University Medical School – sequence: 2 givenname: Xiang surname: Gao fullname: Gao, Xiang organization: Nantong University – sequence: 3 givenname: XiaoJuan surname: Ge fullname: Ge, XiaoJuan organization: Nantong University – sequence: 4 givenname: Jiawen surname: Cui fullname: Cui, Jiawen organization: Zhongshan Hospital of Fudan University – sequence: 5 givenname: Xia surname: Liu fullname: Liu, Xia email: liuxia717@126.com organization: Nantong University Medical School |
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Cites_doi | 10.21873/anticanres.11006 10.1016/j.sjbs.2016.11.007 10.1002/ptr.6201 10.1155/2017/9402198 10.1016/j.ajo.2009.07.007 10.18632/oncotarget.22339 10.3390/ijms19010110 10.1155/2013/540416 10.1136/bmjophth-2016-000021 10.3892/ijo.2015.3130 10.2147/DDDT.S256450 10.3310/hta19510 10.4149/gpb_2019058 10.1016/0166-2236(96)10049-7 10.1007/s00125-019-04998-4 10.2174/1871520617666170327152026 10.1016/j.yexcr.2014.08.040 10.1002/dmrr.415 10.1155/2019/4875421 10.1016/j.vph.2017.01.004 10.2147/OPTH.S143206 10.1155/2018/8546423 10.1007/s12020-014-0232-z 10.1189/jlb.0608385 10.4239/wjd.v7.i16.333 10.1002/biof.1660 10.1016/j.intimp.2010.05.009 10.1007/s12640-019-00102-1 10.1111/j.1755-3768.2012.02430.x 10.15252/emmm.201810154 10.1186/s12974-015-0422-5 10.1097/IIO.0b013e31819fd164 10.1021/acs.jafc.0c03194 10.1016/j.fct.2017.10.008 10.1136/bjo.86.4.363 10.1111/j.1755-3768.2010.02079.x 10.1016/j.jss.2015.06.013 10.1900/RDS.2015.12.159 10.1016/S0161-6420(03)00475-5 10.1016/j.jdiacomp.2019.107417 10.1016/j.freeradbiomed.2020.08.006 10.2147/OPTH.S267521 |
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Keywords | Cyanidin-3-o-glucoside (C3G) neovascularization diabetic retinopathy (DR) microglial activation |
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SubjectTerms | Animals Anthocyanins - pharmacology Anthocyanins - therapeutic use Cell Line Cell Movement - drug effects Cyanidin-3-o-glucoside (C3G) diabetic retinopathy (DR) Diabetic Retinopathy - drug therapy Diabetic Retinopathy - pathology Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelial Cells - pathology Humans Inflammation - pathology Mice Mice, Inbred C57BL Microglia - drug effects Microglia - metabolism Microglia - pathology microglial activation neovascularization Neovascularization, Pathologic - drug therapy Research Paper RNA, Messenger - genetics RNA, Messenger - metabolism |
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Title | Cyanidin-3-o-glucoside (C3G) inhibits vascular leakage regulated by microglial activation in early diabetic retinopathy and neovascularization in advanced diabetic retinopathy |
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