Whole genome sequencing and prediction of antimicrobial susceptibilities in non-tuberculous mycobacteria

• Published in: Frontiers in microbiology Vol. 13; p. 1044515
• Main Authors: Solanki, Priya, Lipman, Marc, McHugh, Timothy D., Satta, Giovanni
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 29.11.2022
• Subjects: Microbiology; mutations; Mycobacterium; non-tuberculous mycobacteria; resistance; sequencing; Mycobacterium; non-tuberculous mycobacteria; mutations; resistance; sequencing

Non-tuberculous mycobacteria (NTM) are opportunistic pathogens commonly causing chronic, pulmonary disease which is notoriously hard to treat. Current treatment for NTM infections involves at least three active drugs (including one macrolide: clarithromycin or azithromycin) over 12 months or longer....