Targeting EZH2-mediated methylation of histone 3 inhibits proliferation of pediatric acute monocytic leukemia cells in vitro

• Published in: Cancer biology & therapy Vol. 22; no. 4; pp. 333 - 344
• Main Authors: Al-Ghabkari, Abdulhameed, Narendran, Aru
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 03.04.2021
• Subjects: AML; Animals; Cell Proliferation; Child; Enhancer of Zeste Homolog 2 Protein - genetics; Enhancer of Zeste Homolog 2 Protein - metabolism; EZH2; histone methylation; Histones - metabolism; hTERT; Humans; Leukemia, Monocytic, Acute; Methylation; Research Paper; THP-1; AML; THP-1; histone methylation; hTERT; EZH2

Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase and a catalytic subunit of the polycomb repressive complex 2 (PRC2) that catalyzes the mono-, di-, and tri-methylation of histone H3 at Lys 27 (H3K27me3) to facilitate chromatin-remodeling and gene-silencing functions. Previous report...