Multifaceted roles of TAX1BP1 in autophagy

• Published in: Autophagy Vol. 19; no. 1; pp. 44 - 53
• Main Authors: White, Jesse, Suklabaidya, Sujit, Vo, Mai Tram, Choi, Young Bong, Harhaj, Edward W.
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 02.01.2023
• Subjects: Aggrephagy; Animals; Apoptosis Regulatory Proteins - metabolism; autophagy; Autophagy - physiology; Fibroblasts - metabolism; host defense; innate immune signaling; Intracellular Signaling Peptides and Proteins - metabolism; Mice; Neoplasm Proteins - metabolism; Review; TAX1BP1; xenophagy; xenophagy; TAX1BP1; autophagy; innate immune signaling; Aggrephagy; host defense

TAX1BP1 is a selective macroautophagy/autophagy receptor that plays a central role in host defense to pathogens and in regulating the innate immune system. TAX1BP1 facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis and regulates...