A Simplified, Noninvasive Stool DNA Test for Colorectal Cancer Detection

• Published in: The American journal of gastroenterology Vol. 103; no. 11; pp. 2862 - 2870
• Main Authors: Itzkowitz, Steven, Brand, Randall, Jandorf, Lina, Durkee, Kris, Millholland, John, Rabeneck, Linda, Schroy, Paul C., Sontag, Stephen, Johnson, David, Markowitz, Sanford, Paszat, Lawrence, Berger, Barry M.
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.11.2008; Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
• Subjects: Biological and medical sciences; Colorectal cancer; Colorectal Neoplasms - diagnosis; DNA - isolation & purification; Feces - chemistry; Gastroenterology; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Medical sciences; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumors; Colonic disease; Rectal disease; DNA; Colorectal cancer; Gastroenterology; Digestive diseases; Intestinal disease; Malignant tumor; Feces; Cancer
• ISSN: 0002-9270; 1572-0241; 1572-0241
• DOI: 10.1111/j.1572-0241.2008.02088.x

As a noninvasive colorectal cancer (CRC) screening test, a multi-marker first generation stool DNA (sDNA V 1.0) test is superior to guaiac-based fecal occult blood tests. An improved sDNA assay (version 2), utilizing only two markers, hypermethylated vimentin gene (hV) and a two site DNA integrity a...