Tetrodotoxin sensitivity of the vertebrate cardiac Na+ current

• Published in: Marine drugs Vol. 9; no. 11; pp. 2409 - 2422
• Main Authors: Vornanen, Matti, Hassinen, Minna, Haverinen, Jaakko
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.11.2011; Molecular Diversity Preservation International
• Subjects: Animals; cardiac sodium current; Dose-Response Relationship, Drug; Drug Resistance; evolution of tetrodotoxin sensitivity; In Vitro Techniques; Myocytes, Cardiac - drug effects; Myocytes, Cardiac - metabolism; Sodium Channels - drug effects; Sodium Channels - metabolism; Species Specificity; Tetrodotoxin - administration & dosage; Tetrodotoxin - toxicity; vertebrate animals; Vertebrates; vertebrate animals; evolution of tetrodotoxin sensitivity; cardiac sodium current

Evolutionary origin and physiological significance of the tetrodotoxin (TTX) resistance of the vertebrate cardiac Na(+) current (I(Na)) is still unresolved. To this end, TTX sensitivity of the cardiac I(Na) was examined in cardiac myocytes of a cyclostome (lamprey), three teleost fishes (crucian car...