Loss of habenular Prkar2a reduces hedonic eating and increases exercise motivation

• Published in: JCI insight Vol. 5; no. 23
• Main Authors: London, Edra, Wester, Jason C, Bloyd, Michelle, Bettencourt, Shelby, McBain, Chris J, Stratakis, Constantine A
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 03.12.2020; American Society for Clinical investigation
• Subjects: Metabolism; Neuroscience; Obesity; Signal transduction; Neuroscience; Behavior; Metabolism

The habenula (Hb) is a bilateral, evolutionarily conserved epithalamic structure connecting forebrain and midbrain structures that has gained attention for its roles in depression, addiction, rewards processing, and motivation. Of its 2 major subdivisions, the medial Hb (MHb) and lateral Hb (LHb), M...